Evidence map›Paper›PMID 30679709›Full record

ArticleScientific reports2019

The structure of the nucleoprotein of Influenza D shows that all Orthomyxoviridae nucleoproteins have a similar NP

Amélie Donchet, Justine Oliva, Alice Labaronne, Laura Tengo, Myriam Miloudi, Francine C A Gerard, Caroline Mas, Guy Schoehn, Rob W H Ruigrok, Mariette Ducatez and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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  11. Structure of an H3N2 influenza virus nucleoprotein.Acta crystallographica. Section F, Structural biology communications · 2021
    Article
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  13. Review
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  15. Article
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  17. AnAvicenna journal of phytomedicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Amélie DonchetInstitut de Biologie Structurale (IBS), Univ. Grenoble Alpes, CEA, CNRS, 38044, Grenoble, France.
Justine OlivaIHAP, Université de Toulouse, INRA, ENVT, Toulouse, France.
Alice LabaronneInstitut de Biologie Structurale (IBS), Univ. Grenoble Alpes, CEA, CNRS, 38044, Grenoble, France.
Laura TengoInstitut de Biologie Structurale (IBS), Univ. Grenoble Alpes, CEA, CNRS, 38044, Grenoble, France.
Myriam MiloudiInstitut de Biologie Structurale (IBS), Univ. Grenoble Alpes, CEA, CNRS, 38044, Grenoble, France.
Francine C A GerardInstitut de Biologie Structurale (IBS), Univ. Grenoble Alpes, CEA, CNRS, 38044, Grenoble, France.
Caroline MasIntegrated Structural Biology Grenoble (ISBG) - UMS 3518 (CNRS-CEA-UJF-EMBL), 38044, Grenoble, France.
Guy SchoehnInstitut de Biologie Structurale (IBS), Univ. Grenoble Alpes, CEA, CNRS, 38044, Grenoble, France.ORCID 0000-0002-1459-3201
Rob W H RuigrokInstitut de Biologie Structurale (IBS), Univ. Grenoble Alpes, CEA, CNRS, 38044, Grenoble, France.
Mariette DucatezIHAP, Université de Toulouse, INRA, ENVT, Toulouse, France.
Thibaut CrépinInstitut de Biologie Structurale (IBS), Univ. Grenoble Alpes, CEA, CNRS, 38044, Grenoble, France. thibaut.crepin@ibs.fr.ORCID 0000-0003-2663-1794
Centre National de la Recherche Scientifique · FRÉcole Nationale Vétérinaire de Toulouse · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper focuses on the nucleoprotein (NP) of the newly identified member of the Orthomyxoviridae family, Influenza D virus. To date several X-ray structures of NP of Influenza A (A/NP) and B (B/NP) viruses and of infectious salmon anemia (ISA/NP) virus have been solved. Here we purified, characterized and solved the X-ray structure of the tetrameric D/NP at 2.4 Å resolution. The crystal structure of its core is similar to NP of other Influenza viruses. However, unlike A/NP and B/NP which possess a flexible amino-terminal tail containing nuclear localization signals (NLS) for their nuclear import, D/NP possesses a carboxy-terminal tail (D/NP

Indexed as

Active Transport, Cell Nucleusalpha KaryopherinsAmino Acid SequenceCell NucleusCrystallography, X-RayHEK293 CellsHumansNucleoproteinsOrthomyxoviridaeProtein BindingProtein Structure, QuaternaryRecombinant ProteinsSequence AlignmentThogotovirusalpha KaryopherinsNucleoproteinsRecombinant Proteins

Identifiers

PMID30679709
PMCPMC6346101
OpenAlexW2913868885

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.