ArticleScientific reports2019
Process calculi may reveal the equivalence lying at the heart of RNA and proteins.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 citing papers in PubMed, 5 citations in OpenAlex.
- RNA secondary structure factorization in prime tangles.BMC bioinformatics · 2022Article
- Structural relation matching: an algorithm to identify structural patterns into RNAs and their interactions.Journal of integrative bioinformatics · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The successful use of process calculi to specify behavioural models allows us to compare RNA and protein folding processes from a new perspective. We model the folding processes as behaviours resulting from the interactions that nucleotides and amino acids (the elementary units that compose RNAs and proteins respectively) perform on their linear sequences. This approach is intended to provide new knowledge about the studied systems without strictly relying on empirical data. By applying Milner's CCS process algebra to highlight the distinguishing features of the two folding processes, we discovered an abstraction level at which they show behavioural equivalences. We believe that this result could be interpreted as a clue in favour of the highly-debated RNA World theory, according to which, in the early stages of cell evolution, RNA molecules played most of the functional and structural roles carried out today by proteins.
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