Trial reportScientific reports2019
Effects of circadian misalignment on cognition in chronic shift workers.
Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Shift work is significantly and positively associated with possible gastro-esophageal reflux disease: A meta-analysis study.Frontiers in public health · 2022Pooled it
- Insomnia in patients treated with checkpoint inhibitors for cancer: A meta-analysis.Frontiers in oncology · 2022Pooled it
- The relationship between circadian type and physical activity as predictors of cognitive performance during simulated nightshifts: A randomised controlled trial.Chronobiology international · 2025Trial
- Resetting of the Human Circadian Melatonin Rhythm by Ambient Hypoxia.Journal of pineal research · 2025Trial
- Improving sleep health in paramedics through an app-based intervention: a randomised waitlist control pilot trial.BMC public health · 2024Trial
- Surgeon Social Jet Lag and Patient Risk of Major Adverse Events.JAMA surgery · 2026Article
- Variable Morning Melatonin Profiles Limit Determination of Dim-Light Melatonin Offset in Preschool-Aged Children.Journal of biological rhythms · 2026Article
- Article
- Twenty-Four-Hour Rest-Activity Rhythms and Epigenetic Age Acceleration in Middle-Aged and Older Adults.JAMA network open · 2026Article
- Control vs. salience: a new axis of circadian brain-body organization.Npj biological timing and sleep · 2026Article
- Do microbiota rhythms influence cognitive performance? - A narrative review.Frontiers in molecular neuroscience · 2026Review
- Chronotype in alpha-tACS: Preliminary evidence hints at sleep quality modulation of aftereffects in evening types in the morning.Neurobiology of sleep and circadian rhythms · 2025Article
- Association Between Shift Work and Auditory-Cognitive Processing in Middle-Aged Healthcare Workers.Audiology research · 2025Article
- The Impact of Polycystic Ovary Syndrome on Mood Disorders: A Cross-Sectional Questionnaire Study on Chronotypes, Social Jetlag, and Night Eating Habits.Journal of clinical medicine · 2025Article
- Occupational and Driving Challenges Within Sleep Medicine.Journal of sleep research · 2025Review
- Prefrontal cortex hypoactivation in response to sleep-related pictures in shift workers.Brain structure & function · 2025Article
- Impact and Interrelationships of Striatal Proteins, EPHB2, OPRM1, and PER2 on Mild Cognitive Impairment.Molecular neurobiology · 2025Article
- Shift work schedules alter immune cell regulation and accelerate cognitive impairment during aging.Journal of neuroinflammation · 2025Article
- Article
- Sleep, Well-Being, and Cognition in Medical Interns on a Float or Overnight Call Schedule.JAMA network open · 2024Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Shift work is associated with increased human operational errors, presumably due to the circadian timing system that inhibits optimal cognitive function during the night. Circadian misalignment, which is the misalignment between the circadian pacemaker and behavioral/environmental cycles, impairs cognitive performance in non-shift workers. However, it remains uncertain whether the adverse cognitive consequences of circadian misalignment are also observed in chronic shift workers. Thus, we investigated the effects of circadian misalignment on cognitive performance in chronic shift workers. Using a randomized, cross-over design that simulated day shift work (circadian alignment) and night shift work (circadian misalignment), we show that circadian misalignment increases cognitive vulnerability on sustained attention, information processing and visual-motor performance, particularly after more than 10 hours of scheduled wakefulness. Furthermore, their increased levels of subjective sleepiness and their decreased sleep efficiency were significantly associated with impaired sustained attention and visual-motor performance. Our data suggest that circadian misalignment dramatically deteriorates cognitive performance in chronic shift workers under circadian misalignment. This increased cognitive vulnerability may have important safety consequences, given the increasing number of nighttime jobs that crucially rely on the availability of cognitive resources.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.