ArticleScientific reports2019
Through synapses to spatial memory maps via a topological model.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Spaces and sequences in the hippocampus: a homological perspective.Journal of computational neuroscience · 2026Article
- Unusual Mathematical Approaches Untangle Nervous Dynamics.Biomedicines · 2022Review
- Spatial representability of neuronal activity.Scientific reports · 2021Article
- The grid code for ordered experience.Nature reviews. Neuroscience · 2021Review
- The thermodynamics of cognition: A mathematical treatment.Computational and structural biotechnology journal · 2021Article
- Is there a primitive reflex residue underlying Marcus Gunn Syndrome? Rat electrophysiology.International journal of ophthalmology · 2020Article
- From Topological Analyses to Functional Modeling: The Case of Hippocampus.Frontiers in computational neuroscience · 2020Article
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Authors and funding
1 author.
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Abstract
Various neurophysiological and cognitive functions are based on transferring information between spiking neurons via a complex system of synaptic connections. In particular, the capacity of presynaptic inputs to influence the postsynaptic outputs-the efficacy of the synapses-plays a principal role in all aspects of hippocampal neurophysiology. However, a direct link between the information processed at the level of individual synapses and the animal's ability to form memories at the organismal level has not yet been fully understood. Here, we investigate the effect of synaptic transmission probabilities on the ability of the hippocampal place cell ensembles to produce a cognitive map of the environment. Using methods from algebraic topology, we find that weakening synaptic connections increase spatial learning times, produce topological defects in the large-scale representation of the ambient space and restrict the range of parameters for which place cell ensembles are capable of producing a map with correct topological structure. On the other hand, the results indicate a possibility of compensatory phenomena, namely that spatial learning deficiencies may be mitigated through enhancement of neuronal activity.
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