ArticleScientific reports2019
Comparative prevalence of Oxalobacter formigenes in three human populations.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The gut-kidney microbiome-oxalate axis in calcium oxalate nephrolithiasis: mechanisms and microbiome-based interventions.Frontiers in cellular and infection microbiology · 2026Pooled it
- Quantitative detection of gut microbial eukaryotes with EukDetect2 reveals global distribution of commensal protists and association with distinct microbial community structure.bioRxiv : the preprint server for biology · 2026Article
- InducingKidney international reports · 2025Article
- Causal relationship between kidney stones and gut microbiota contributes to the gut-kidney axis: a two-sample Mendelian randomization study.Frontiers in microbiology · 2023Article
- Probiotic Oxalate-Degrading Bacteria: New Insight of Environmental Variables and Expression of the oxc and frc Genes on Oxalate Degradation Activity.Foods (Basel, Switzerland) · 2022Review
- Review
- Demonstrating the role of symbionts in mediating detoxification in herbivores.Symbiosis (Philadelphia, Pa.) · 2022Article
- Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome.Nature genetics · 2022Observational
- Forty Years of Oxalobacter formigenes, a Gutsy Oxalate-Degrading Specialist.Applied and environmental microbiology · 2021Review
- Effect of antibiotic treatment on Oxalobacter formigenes colonization of the gut microbiome and urinary oxalate excretion.Scientific reports · 2021Article
- Article
- Interaction of Intestinal Bacteria with Human Rotavirus during Infection in Children.International journal of molecular sciences · 2021Article
- Contribution of Dietary Oxalate and Oxalate Precursors to Urinary Oxalate Excretion.Nutrients · 2020Review
- The Midgut Microbiota of ColombianInsects · 2020Article
- Calcium Oxalate Nephrolithiasis and Gut Microbiota: Not just a Gut-Kidney Axis. A Nutritional Perspective.Nutrients · 2020Review
- Development of a Humanized Murine Model for the Study of Oxalobacter formigenes Intestinal Colonization.The Journal of infectious diseases · 2019Article
- The use of antibiotics and risk of kidney stones.Current opinion in nephrology and hypertension · 2019Review
- Current update and future directions on gut microbiome and nephrolithiasis.Indian journal of urology : IJU : journal of the Urological Society of IndiaReview
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
There has been increasing interest in the human anaerobic colonic bacterium Oxalobacter formigenes because of its ability to metabolize oxalate, and its potential contribution to protection from calcium oxalate kidney stones. Prior studies examining the prevalence of this organism have focused on subjects in developed countries and on adults. Now using O. formigenes-specific PCR, we have compared the prevalence of these organisms among subjects in two remote areas in which modern medical practices have hardly been present with a USA group of mothers and their infants for the first three years of life. Among the Amerindians of the Yanomami-Sanema and Yekwana ethnic groups in Venezuela and the Hadza in Tanzania, O. formigenes was detected in 60-80% of the adult subjects, higher than found in adults from USA in this and prior studies. In young children, the prevalence was much lower in USA than in either tribal village. These data extend our understanding of the epidemiology of O. formigenes carriage, and are consistent with the hypothesis that the rising incidence of kidney stones is associated with the progressive loss of O. formigenes colonization in populations that have been highly impacted by modern medical practices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.