ArticleScientific reports2019
Positively interacting strains that co-circulate within a network structured population induce cycling epidemics of Mycoplasma pneumoniae.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Post-pandemic resurgence and collapse ofFrontiers in public health · 2026Article
- Etiological composition and epidemiological characteristics of acute respiratory infections in Hebei Province, 2023-2025.Frontiers in public health · 2026Article
- Analysis of the epidemic situation of respiratory pathogens in central and southern China before and after the COVID-19 pandemic.Frontiers in pediatrics · 2026Article
- Complex multiannual cycles ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Clinical characteristics and outcomes of macrolide-resistantTranslational pediatrics · 2025Article
- A landscape-scale field survey demonstrates the role of wheat volunteers as a local and diversified source of leaf rust inoculum.Scientific reports · 2023Article
- [Macrolide-resistant Mycoplasma pneumoniae: Do we know the situation in Europe?]Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023Review
- Molecular Tools for TypingFrontiers in microbiology · 2022Review
- The clinical characteristics ofTranslational pediatrics · 2021Article
- Molecular Characterization of Mycoplasma pneumoniae Isolates in the United States from 2012 to 2018.Journal of clinical microbiology · 2020Article
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
- Integrating mathematical models with experimental data to investigate the within-host dynamics of bacterial infections.Pathogens and disease · 2019Review
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4 authors.
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Abstract
Mycoplasma pneumoniae (MP) is considered a common cause of pneumonia, causing about 15-20% of adult community-acquired pneumonia (CAP) and up to 40% of cases in children. It has often been observed that MP epidemics last approximately 1-2 years and occur every 3-7 years, with the dominant strains alternating between epidemics. However, the underlying mechanism by which these cycles and changes in the dominant strains occur remains unclear. The traditional models for the periodicity of MP epidemics neglected two phenomena: structured contact patterns among people and co-circulating strains of MP. We also believe that the two distinctive aspects of MP epidemics: prevalent serotype shifts among epidemics and incidence cycling of MP, are interconnected. We propose a network transmission model that assumes two strains of MP are transmitted within a network structured population and they can interact as secondary infections with primary infections. Our studies show that multiple strains that co-circulate within a network structured population and interact positively generate the observed patterns of recurrent epidemics of MP. Hence our study provides a possible mechanism for the cycling epidemics of MP, and could provide useful information for future vaccine design and vaccine evaluation/monitoring processes.
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