ArticleNature communications2019
Medial geniculate body and primary auditory cortex differentially contribute to striatal sound representations.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Auditory associative learning drives synaptic responses in tail of the striatum spiny projection neurons.iScience · 2026Article
- Hearing Loss and Parkinson's Disease: Insights From Human and Animal Studies.Brain and behavior · 2026Article
- Brain-wide atlas of outputs and inputs of mouse auditory cortex revealed by modified viral labeling strategies.Fundamental research · 2026Article
- A cortical output channel for perceptual categorization.Science advances · 2026Article
- Indirect pathway neurons in the tail of the striatum regulate inhibitory control over sensory driven behavior.Science advances · 2026Article
- Learning shapes neural codes for sensory-motor integration in the tail of the striatum.bioRxiv : the preprint server for biology · 2026Article
- Layer 5 and 6b extratelencephalic neurons encode distinct sound features in auditory cortex.bioRxiv : the preprint server for biology · 2026Article
- Decoding auditory cognition: Unraveling the corticostriatal-SNr circuit's role in frequency discrimination accuracy.iScience · 2025Article
- Mid-infrared photons relieve tinnitus-like behavior of mice by regulating HCN2 ion channels in the medial geniculate body.Annals of medicine · 2025Article
- Article
- Brain-wide coordination of internal signals during decision-making.bioRxiv : the preprint server for biology · 2025Article
- A disinhibitory microcircuit in the temporal association cortex for fear retrieval to pure tones.Scientific reports · 2025Article
- An auditory cortical-striatal circuit supports sound-triggered timing to predict future events.PLoS biology · 2025Article
- Safety learning induces postsynaptic potentiation of direct pathway spiny projection neurons in the tail of the striatum.bioRxiv : the preprint server for biology · 2025Article
- A midbrain circuit mechanism for noise-induced negative valence coding.Nature communications · 2025Article
- Article
- The zona incerta negatively regulates the red nucleus during movement cued by sound signals.PLoS biology · 2025Article
- Locomotion-dependent auditory gating to the parietal cortex guides multisensory decisions.Nature communications · 2025Article
- Article
- Neural circuit mechanisms underlying aberrantly prolonged functional hyperemia in young Alzheimer's disease mice.Molecular psychiatry · 2025Article
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4 authors.
Funding
Abstract
The dorsal striatum has emerged as a key region in sensory-guided, reward-driven decision making. A posterior sub-region of the dorsal striatum, the auditory striatum, receives convergent projections from both auditory thalamus and auditory cortex. How these pathways contribute to auditory striatal activity and function remains largely unknown. Here we show that chemogenetic inhibition of the projections from either the medial geniculate body (MGB) or primary auditory cortex (ACx) to auditory striatum in mice impairs performance in an auditory frequency discrimination task. While recording striatal sound responses, we find that transiently silencing the MGB projection reduced sound responses across a wide-range of frequencies in striatal medium spiny neurons. In contrast, transiently silencing the primary ACx projection diminish sound responses preferentially at the best frequencies in striatal medium spiny neurons. Together, our findings reveal that the MGB projection mainly functions as a gain controller, whereas the primary ACx projection provides tuning information for striatal sound representations.
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