Evidence map›Paper›PMID 30679380›Full record

ArticleJournal of the American Society of Nephrology : JASN2019

Excess Deaths Attributable to Influenza-Like Illness in the ESRD Population.

David T Gilbertson, Kenneth J Rothman, Glenn M Chertow, Brian D Bradbury, M Alan Brookhart, Jiannong Liu, Wolfgang C Winkelmayer, Til Stürmer, Keri L Monda, Charles A Herzog and 3 more

Abstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Antibody Response to COVID-19 vaccination in Patients Receiving Dialysis.medRxiv : the preprint server for health sciences · 2021
    Article
  10. Review
  11. Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021
    Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. The aftermath of coronavirus disease 2019: devastation or a new dawn for nephrology?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

David T GilbertsonChronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, Minnesota; dgilbertson@cdrg.org.
Kenneth J RothmanResearch Triangle Institute Health Solutions, Research Triangle Park, North Carolina.
Glenn M ChertowDepartment of Medicine, Stanford University School of Medicine, Palo Alto, California.
Brian D BradburyCenter for Observational Research, Amgen, Inc., Thousand Oak, California.
M Alan BrookhartGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Jiannong LiuChronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, Minnesota.
Wolfgang C WinkelmayerDepartment of Medicine-Nephrology, Baylor College of Medicine, Houston, Texas.
Til StürmerGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Keri L MondaCenter for Observational Research, Amgen, Inc., Thousand Oak, California.
Charles A HerzogChronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, Minnesota.
Akhtar AshfaqRenal Division, Opko Pharmaceuticals, Miami, Florida.
Allan J CollinsDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota.
James B WetmoreChronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, Minnesota.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMorbidity and mortality vary seasonally. Timing and severity of influenza seasons contribute to those patterns, especially among vulnerable populations such as patients with ESRD. However, the extent to which influenza-like illness (ILI), a syndrome comprising a range of potentially serious respiratory tract infections, contributes to mortality in patients with ESRD has not been quantified.

methodsWe used data from the Centers for Disease Control and Prevention (CDC) Outpatient Influenza-like Illness Surveillance Network and Centers for Medicare and Medicaid Services ESRD death data from 2000 to 2013. After addressing the increasing trend in deaths due to the growing prevalent ESRD population, we calculated quarterly relative mortality compared with average third-quarter (summer) death counts. We used linear regression models to assess the relationship between ILI data and mortality, separately for quarters 4 and 1 for each influenza season, and model parameter estimates to predict seasonal mortality counts and calculate excess ILI-associated deaths.

resultsAn estimated 1% absolute increase in quarterly ILI was associated with a 1.5% increase in relative mortality for quarter 4 and a 2.0% increase for quarter 1. The average number of annual deaths potentially attributable to ILI was substantial, about 1100 deaths per year.

conclusionsWe found an association between community ILI activity and seasonal variation in all-cause mortality in patients with ESRD, with ILI likely contributing to >1000 deaths annually. Surveillance efforts, such as timely reporting to the CDC of ILI activity within dialysis units during influenza season, may help focus attention on high-risk periods for this vulnerable population.

Indexed as

HumansInfluenza, HumanKidney Failure, ChronicKidney TransplantationRenal DialysisSeasonsTime FactorsUnited StatesESRDinfluenzainfluenza-like illnessmortality

Identifiers

PMID30679380
PMCPMC6362626

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.