Evidence map›Paper›PMID 30679328›Full record

ArticleHaematologica2019

Blockade of crizotinib-induced BCL2 elevation in ALK-positive anaplastic large cell lymphoma triggers autophagy associated with cell death.

Avedis Torossian, Nicolas Broin, Julie Frentzel, Camille Daugrois, Sarah Gandarillas, Talal Al Saati, Laurence Lamant, Pierre Brousset, Sylvie Giuriato, Estelle Espinos

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

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  14. Regulation of Beclin 1-Mediated Autophagy by Oncogenic Tyrosine Kinases.International journal of molecular sciences · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Avedis TorossianInserm, UMR1037 CRCT, F-31000 Toulouse, France.
Nicolas BroinInserm, UMR1037 CRCT, F-31000 Toulouse, France.
Julie FrentzelInserm, UMR1037 CRCT, F-31000 Toulouse, France.
Camille DaugroisInserm, UMR1037 CRCT, F-31000 Toulouse, France.
Sarah GandarillasInserm/UPS, US006/CREFRE, F-31000 Toulouse, France.
Talal Al SaatiInserm/UPS, US006/CREFRE, Service d'Histopathologie, F-31000 Toulouse, France.
Laurence LamantInserm, UMR1037 CRCT, F-31000 Toulouse, France.
Pierre BroussetInserm, UMR1037 CRCT, F-31000 Toulouse, France.
Sylvie GiuriatoInserm, UMR1037 CRCT, F-31000 Toulouse, France estelle.espinos@inserm.fr sylvie.giuriato@inserm.fr.
Estelle EspinosInserm, UMR1037 CRCT, F-31000 Toulouse, France estelle.espinos@inserm.fr sylvie.giuriato@inserm.fr.
Centre National de la Recherche Scientifique · FRUniversité Toulouse III - Paul Sabatier · FRUniversité Fédérale de Toulouse Midi-Pyrénées · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphomas are tumors that carry translocations involving the

Indexed as

AutophagyAnaplastic Lymphoma KinaseAnimalsAntineoplastic AgentsCell DeathCell ProliferationCrizotinibGene Expression Regulation, NeoplasticHumansLymphoma, Large-Cell, AnaplasticMiceMice, Inbred NODMice, SCIDPrognosisProto-Oncogene Proteins c-bcl-2Tumor Cells, CulturedALK protein, humanAnaplastic Lymphoma KinaseAntineoplastic AgentsBCL2 protein, humanCrizotinibProto-Oncogene Proteins c-bcl-2

Identifiers

PMID30679328
PMCPMC6601090
OpenAlexW2911967146

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.