Evidence map›Paper›PMID 30679325›Full record

ArticleHaematologica2019

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between

Clara Bueno, Fernando J Calero-Nieto, Xiaonan Wang, Rafael Valdés-Mas, Francisco Gutiérrez-Agüera, Heleia Roca-Ho, Veronica Ayllon, Pedro J Real, David Arambilet, Lluis Espinosa and 8 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. A Benchmark Side-by-Side Comparison of Two Well-Established Protocols forFrontiers in cell and developmental biology · 2021
    Article
  8. Review
  9. The MLL/SET family and haematopoiesis.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020
    Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 3 countries.

Clara BuenoJosep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Spain cbueno@carrerasresearch.org pmenendez@carrerasresearch.org.
Fernando J Calero-NietoDepartment of Hematology, Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, UK.
Xiaonan WangDepartment of Hematology, Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, UK.
Rafael Valdés-MasDreamgenics S.L. Oviedo. Spain.
Francisco Gutiérrez-AgüeraJosep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Spain.
Heleia Roca-HoJosep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Spain.
Veronica AyllonGENyO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government and University of Granada, Department of Biochemistry and Molecular Biology, Granada, Spain.
Pedro J RealGENyO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government and University of Granada, Department of Biochemistry and Molecular Biology, Granada, Spain.
David ArambiletPrograma de Cáncer, Instituto Hospital del Mar de Investigaciones Médicas. Barcelona. Spain.
Lluis EspinosaPrograma de Cáncer, Instituto Hospital del Mar de Investigaciones Médicas. Barcelona. Spain.
Raul Torres-RuizJosep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Spain.
Antonio Agraz-DoblasJosep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Spain.
Ignacio VarelaInstituto de Biomedicina y Biotecnología de Cantabria (CSIC-UC-Sodercan), Departamento de Biología Molecular, Universidad de Cantabria, Santander, Spain.
Jasper de BoerCancer Section, UCL Great Ormond Street Institute of Child Health, London, UK.
Anna BigasPrograma de Cáncer, Instituto Hospital del Mar de Investigaciones Médicas. Barcelona. Spain.
Bertie GottgensDepartment of Hematology, Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, UK.
Rolf MarschalekInstitute of Pharmaceutical Biology, Goethe-University, Frankfurt, Germany.
Pablo MenendezJosep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Spain cbueno@carrerasresearch.org pmenendez@carrerasresearch.org.
Josep Carreras Leukaemia Research Institute · ESInstituto de Biomedicina y Biotecnología de Cantabria · ESInstituto de Salud Carlos III · ESPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research · ESUniversity of Cambridge · GBCentro de Investigación Biomédica en Red de Cáncer · ESGoethe University Frankfurt · DEGreat Ormond Street Hospital · GBInstitució Catalana de Recerca i Estudis Avançats · ESMedical Research Council · GB

Funding

Cancer Research UK 21762Medical Research Council MC_PC_12009Medical Research Council MR/M008975/1Medical Research Council MR/S036113/1
6 · The paper itself

Abstract

The t(4;11)(q21;q23) translocation is associated with high-risk infant pro-B-cell acute lymphoblastic leukemia and arises prenatally during embryonic/fetal hematopoiesis. The developmental/pathogenic contribution of the t(4;11)-resulting

Indexed as

AnimalsApoptosisCell CycleCell DifferentiationCoculture TechniquesEmbryonic DevelopmentEndothelial CellsHematopoiesisHematopoietic Stem CellsHistonesHuman Embryonic Stem CellsHumansMethylationMiceMice, KnockoutMyeloid-Lymphoid Leukemia ProteinHistonesMLL-AF4 fusion protein, humanMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, Fusion

Identifiers

PMID30679325
PMCPMC6545840
OpenAlexW2913012303

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.