Evidence map›Paper›PMID 30679323›Full record

ArticleHaematologica2019

Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis.

Antonio Agraz-Doblas, Clara Bueno, Rachael Bashford-Rogers, Anindita Roy, Pauline Schneider, Michela Bardini, Paola Ballerini, Gianni Cazzaniga, Thaidy Moreno, Carlos Revilla and 8 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Haematologica · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Only InfantInternational journal of molecular sciences · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Aberrant stem cell and developmental programs in pediatric leukemia.Frontiers in cell and developmental biology · 2024
    Review
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 4 countries.

Antonio Agraz-DoblasInstituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC, Santander, Spain.
Clara BuenoJosep Carreras Leukemia Research Institute-Campus Clinic, Department of Biomedicine, School of Medicine, University of Barcelona, Spain.
Rachael Bashford-RogersDepartment of Medicine, University of Cambridge, Cambridge Biomedical Campus, UK.
Anindita RoyDepartment of Paediatrics, University of Oxford, UK.
Pauline SchneiderPrincess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Michela BardiniCentro Ricerca Tettamanti, Department of Pediatrics, University of Milano Bicocca, Fondazione MBBM, Monza, Italy.
Paola BalleriniPediatric Hematology, A. Trousseau Hospital, Paris, France.
Gianni CazzanigaCentro Ricerca Tettamanti, Department of Pediatrics, University of Milano Bicocca, Fondazione MBBM, Monza, Italy.
Thaidy MorenoInstituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC, Santander, Spain.
Carlos RevillaInstituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC, Santander, Spain.
Marta GutCNAG-CRG, Center for Genomic Regulation, Barcelona, Spain.
Maria G ValsecchiInterfant Trial Data Center, University of Milano-Bicocca, Monza, Italy.
Irene RobertsDepartment of Paediatrics, University of Oxford, UK.
Rob PietersPrincess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Paola De LorenzoInterfant Trial Data Center, University of Milano-Bicocca, Monza, Italy.
Ignacio VarelaInstituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC, Santander, Spain pmenendez@carrerasresearch.org Ignacio.varela@unican.es.
Pablo MenendezJosep Carreras Leukemia Research Institute-Campus Clinic, Department of Biomedicine, School of Medicine, University of Barcelona, Spain pmenendez@carrerasresearch.org Ignacio.varela@unican.es.
Ronald W StamPrincess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.
University of Milano-Bicocca · ITJosep Carreras Leukaemia Research Institute · ESPrincess Máxima Center · NLUniversidad de Cantabria · ESCentre for Genomic Regulation · ESMRC Weatherall Institute of Molecular Medicine · GBUniversity of Cambridge · GBUniversity of Oxford · GB

Funding

Medical Research Council MC_UU_00016/13Medical Research Council MR/R006237/1Wellcome Trust
6 · The paper itself

Abstract

B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of t(4;11)/KMT2A-AFF1

Indexed as

Biomarkers, TumorDisease SusceptibilityGenome-Wide Association StudyBiopsyBone MarrowChromosome AberrationsGene Expression ProfilingGene RearrangementGenomic InstabilityHistone-Lysine N-MethyltransferaseHomeodomain ProteinsHumansIn Situ Hybridization, FluorescenceMutationMyeloid-Lymphoid Leukemia ProteinPhosphatidylinositol 3-KinasesBiomarkers, TumorHistone-Lysine N-MethyltransferaseHomeodomain ProteinsHoxA proteinKMT2A protein, humanMyeloid-Lymphoid Leukemia ProteinPhosphatidylinositol 3-Kinasesras Proteins

Identifiers

PMID30679323
PMCPMC6545849
OpenAlexW2912654636

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.