Evidence map›Paper›PMID 30679308›Full record

ArticleGenome research2019

Fast and flexible bacterial genomic epidemiology with PopPUNK.

John A Lees, Simon R Harris, Gerry Tonkin-Hill, Rebecca A Gladstone, Stephanie W Lo, Jeffrey N Weiser, Jukka Corander, Stephen D Bentley, Nicholas J Croucher

Abstract read
In one paragraph

Article in Genome research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 292 papers.

0numbers the graph read from it
0cells of the map it votes in
292citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

292 citing papers in PubMed.

  1. Article
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  6. Phenotypic and genotypic characterization ofJAC-antimicrobial resistance · 2026
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  8. Translation accuracy in E. coli.Nucleic acids research · 2026
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  9. Microbial genomics · 2026
    Article
  10. Article
  11. Novel transposon TnMicrobial genomics · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

232 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

John A LeesDepartment of Microbiology, New York University School of Medicine, New York, New York 10016, USA.ORCID 0000-0001-5360-1254
Simon R HarrisParasites and Microbes, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, United Kingdom.ORCID 0000-0003-1512-6194
Gerry Tonkin-HillParasites and Microbes, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, United Kingdom.ORCID 0000-0003-4397-2224
Rebecca A GladstoneParasites and Microbes, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, United Kingdom.ORCID 0000-0002-7993-3051
Stephanie W LoParasites and Microbes, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, United Kingdom.ORCID 0000-0002-2182-0222
Jeffrey N WeiserDepartment of Microbiology, New York University School of Medicine, New York, New York 10016, USA.ORCID 0000-0001-7168-8090
Jukka CoranderParasites and Microbes, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, United Kingdom.ORCID 0000-0002-7752-1942
Stephen D BentleyParasites and Microbes, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, United Kingdom.ORCID 0000-0001-8094-3751
Nicholas J CroucherMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, United Kingdom.ORCID 0000-0001-6303-8768

Funding

ROLE OF OPACITY VARIATION IN PNEUMOCOCCAL PATHOGENESISR01AI038446 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WEISER, JEFFREY NEAL · 1996 to 2019
$7.4M
Mechanisms of Pneumococcal Persistence During CarriageR37AI038446 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jeffrey Neal Weiser · 2020 to 2026
$3.8M
Early Events in Pneumococcal ColonizationR01AI105168 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WEISER, JEFFREY NEAL · 2014 to 2018
$2.1M
Medical Research Council MR/R003076/1Medical Research Council MR/R015600/1NIAID NIH HHS R01 AI038446NIAID NIH HHS R01 AI105168NIAID NIH HHS R37 AI038446Wellcome TrustWellcome Trust 098051Wellcome Trust 104169/Z/14/Z
6 · The paper itself

Abstract

The routine use of genomics for disease surveillance provides the opportunity for high-resolution bacterial epidemiology. Current whole-genome clustering and multilocus typing approaches do not fully exploit core and accessory genomic variation, and they cannot both automatically identify, and subsequently expand, clusters of significantly similar isolates in large data sets spanning entire species. Here, we describe PopPUNK (

Indexed as

Genome, BacterialSoftwareBacteriaBacterial InfectionsBacterial Typing TechniquesGenetic VariationGenomics

Identifiers

PMID30679308
PMCPMC6360808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.