Evidence map›Paper›PMID 30679294›Full record

ArticleBMJ open2019

Does price regulation affect atorvastatin sales in India? An impact assessment through interrupted time series analysis.

Sakthivel Selvaraj, Habib Hasan Farooqui, Aashna Mehta

Abstract read
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sakthivel SelvarajHealth Economics and Financing, Public Health Foundation of India, New Delhi, Delhi, India.
Habib Hasan FarooquiIndian Institute of Public Health - Delhi, Public Health Foundation of India, New Delhi, Delhi, India.ORCID 0000-0002-3081-2929
Aashna MehtaHealth Economics and Financing, Public Health Foundation of India, New Delhi, Delhi, India.

Funding

Wellcome TrustWellcome Trust 084754/Z/08/A
6 · The paper itself

Abstract

objectiveThe objective of this study was to examine the impact of medicines price regulation (Drug Price Control Order, 2013) on the market share of atorvastatin in the Indian retail market for statins.

settingAll Indian states, January 2012 to December 2015.

designQuasi-experimental-interrupted time series analysis. DATA: Pharmaceutical sales audit data set from IMS Health (now IQVIA) for the 48-month period from January 2012 to December 2015. OUTCOME MEASURE: Share of atorvastatin (in percentage) in the Indian market for statins in terms of sales volumes.

resultsWe observed that the price regulation notification (Drug Price Control Orders, 2013) was associated with 0.12% (p<0.001; 95% CI 0.06 to 0.18) increase in the trend of the average monthly market share of atorvastatin (5 mg and 10 mg). After 31 months of price ceilings notification, the average market share of atorvastatin was 3.41% higher than would have been expected had the price ceilings not been notified. In sensitivity analysis, with a control, our findings remain robust, we observed a 0.16% (p<0.001; 95% CI 0.08 to 0.24) rise in the trend of average monthly market share of atorvastatin (5 mg and 10 mg) as compared with the change in the control.

conclusionsPrice control as a public intervention did improve the relative sales of atorvastatin in the statin market in India.

Indexed as

AtorvastatinCommerceCosts and Cost AnalysisDrug IndustryHealth ExpendituresHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIndiaInterrupted Time Series AnalysisLegislation, DrugAtorvastatinHydroxymethylglutaryl-CoA Reductase Inhibitorsatorvastatinindiaout of pocket expenditureprice controlstatin

Identifiers

PMID30679294
PMCPMC6347882

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.