Evidence map›Paper›PMID 30679247›Full record

ArticleG3 (Bethesda, Md.)2019

Environmental and Evolutionary Drivers of the Modular Gene Regulatory Network Underlying Phenotypic Plasticity for Stress Resistance in the Nematode

Kristin L Sikkink, Rose M Reynolds, Catherine M Ituarte, William A Cresko, Patrick C Phillips

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Molecular mechanisms underlying the evolution of a color polyphenism by genetic accommodation in the tobacco hornworm,Proceedings of the National Academy of Sciences of the United States of America · 2025
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  12. SEGN: Inferring real-time gene networks mediating phenotypic plasticity.Computational and structural biotechnology journal · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kristin L SikkinkInstitute of Ecology and Evolution, University of Oregon, Eugene, Oregon 97403.ORCID 0000-0002-0805-0622
Rose M ReynoldsInstitute of Ecology and Evolution, University of Oregon, Eugene, Oregon 97403.
Catherine M ItuarteInstitute of Ecology and Evolution, University of Oregon, Eugene, Oregon 97403.
William A CreskoInstitute of Ecology and Evolution, University of Oregon, Eugene, Oregon 97403 pphil@uoregon.edu wcresko@uoregon.edu.ORCID 0000-0002-3496-8074
Patrick C PhillipsInstitute of Ecology and Evolution, University of Oregon, Eugene, Oregon 97403 pphil@uoregon.edu wcresko@uoregon.edu.ORCID 0000-0001-7271-342X
University of Oregon · US

Funding

THE MATHEMATICAL DEMOGRAPHY OF BIODEMOGRAPHYP01AG022500 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI CAREY, JAMES R. · 2003 to 2010
$8.1M
Functional and population genomics of small RNA regulationR01GM096008 · NIGMS · UNIVERSITY OF OREGON · PI CUTTER, ASHER DAMON, PHILLIPS, PATRICK C. · 2011 to 2014
$1.5M
Systems genetics of natural variation in stress response pathwaysR01GM102511 · NIGMS · UNIVERSITY OF OREGON · PI PHILLIPS, PATRICK C. · 2015 to 2018
$1.1M
Advancing the Scientific Potential of Transcriptomics in Aquatic ModelsR24RR032670 · NCRR · UNIVERSITY OF OREGON · PI CRESKO, WILLIAM A, POSTLETHWAIT, JOHN H. · 2011 to 2011
$553k
An experimental model for stochastic biodemographyR21AG043988 · NIA · UNIVERSITY OF OREGON · PI PHILLIPS, PATRICK C. · 2012 to 2013
$355k
Genetic basis of natural variation in longevity and stress resistanceF32AG032900 · NIA · UNIVERSITY OF OREGON · PI REYNOLDS, ROSE M · 2008 to 2011
$150k
NCRR NIH HHS R24 RR032670NIA NIH HHS F32 AG032900NIA NIH HHS P01 AG022500NIA NIH HHS R21 AG043988NIGMS NIH HHS R01 GM096008NIGMS NIH HHS R01 GM102511
6 · The paper itself

Abstract

Organisms can cope with stressful environments via a combination of phenotypic plasticity at the individual level and adaptation at the population level. Changes in gene expression can play an important role in both. Significant advances in our understanding of gene regulatory plasticity and evolution have come from comparative studies in the field and laboratory. Experimental evolution provides another powerful path by which to learn about how differential regulation of genes and pathways contributes to both acclimation and adaptation. Here we present results from one such study using the nematode

Indexed as

Adaptation, PhysiologicalGene Regulatory NetworksHeat-Shock ResponseOxidative StressTranscriptomeAnimalsCaenorhabditisSequence Analysis, RNACaenorhabditis remaneiexperimental evolutionheat stressoxidative stressRNA-seqtranscriptional network

Identifiers

PMID30679247
PMCPMC6404610
OpenAlexW2792191029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.