ArticleAJNR. American journal of neuroradiology2019
Acute Toxic Leukoencephalopathy: Etiologies, Imaging Findings, and Outcomes in 101 Patients.
Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- The silent consequence of overdose: The case for brain injury-informed opioid treatment.Addiction (Abingdon, England) · 2026Article
- A Review of the Role of Neuroimaging in Neurotoxicity Monitoring in Children with Acute Lymphoblastic Leukemia.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Chronic Central Nervous System Graft-Versus-Host Disease to Unravel Progressive Visual Loss and Ischemic Stroke Recurrence Post-Allogeneic Hematopoietic Stem Cell Transplant: A Case Report.International journal of molecular sciences · 2025Article
- Linezolid induced acute toxic leukoencephalopathy and severe thrombocytopenia presenting as stroke mimic-a case report.Oxford medical case reports · 2024Article
- CHANTER syndrome in the context of pain medication: a case report.BMC neurology · 2024Article
- Clinical and neuroradiographic features of fentanyl inhalation-induced leukoencephalopathy.BMJ case reports · 2024Article
- Prognosis in substance abuse-related acute toxic leukoencephalopathy: A scoping review.Journal of the neurological sciences · 2022Article
- Toxic leukoencephalopathy with axonal spheroids caused by chemotherapeutic drugs other than methotrexate.BMC neurology · 2022Article
- Toxic and metabolic leukoencephalopathies in emergency department patients: a primer for the radiologist.Emergency radiology · 2022Review
- Case Report: MRI, Clinical, and Pathological Correlates of Bromethalin Toxicosis in Three Dogs.Frontiers in veterinary science · 2022Article
- Article
- Chemoradiation induced multiple sclerosis-like demyelination.eNeurologicalSci · 2021Article
- Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments.BMC neurology · 2021Article
- Implications for White Matter Vulnerability to Anti-interleukin-6 Receptor Antibody Treatment.Internal medicine (Tokyo, Japan) · 2020Article
- Potentially Reversible and Recognizable Acute Encephalopathic Syndromes: Disease Categorization and MRI Appearances.AJNR. American journal of neuroradiology · 2020Review
- Pediatric Acute Toxic Leukoencephalopathy: Prediction of the Clinical Outcome by FLAIR and DWI for Various Etiologies.AJNR. American journal of neuroradiology · 2020Article
- Methadone-induced Toxic Encephalopathy In Pediatric Patients: Two Case Reports.Journal of radiology case reports · 2019Article
- Sequential occurrence of eclampsia-associated posterior reversible encephalopathy syndrome and reversible splenial lesion syndrome (a case report): proposal of a novel pathogenesis for reversible splenial lesion syndrome.BMC medical imaging · 2019Article
- "CHOICES": An acronym to aid in delineating potential causes of non-metabolic, non-infectious acute toxic leukoencephalopathy.European journal of radiology open · 2019Review
- Tacrolimus Induced Leukoencephalopathy and Stroke-Like Symptoms: Case Report.Child neurology openArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePrior studies regarding acute toxic leukoencephalopathy (ATL) are either small, or preliminary. Our aim was to evaluate etiologies of and differences in imaging severity and outcomes among various etiologies of ATL. MATERIALS AND
methodsMRIs of patients with suspected ATL over 15 years were retrospectively reviewed; inclusion criteria were: MRI <3 weeks of presentation with both DWI and FLAIR. These were jointly graded by two neuroradiologists via a previously described score of severity. Clinical outcome was evaluated via both modified Rankin (mRS) and ATL outcome (ATLOS) scores, each being correlated with the DWI and FLAIR scores. Etiologic subgroups of
resultsOf 101 included patients, the 4 subgroups of
conclusionsClinical outcomes of ATL vary on the basis of etiology, being worse in chemotherapeutic- and opiate-related ATL. Uremia may be a predisposing or exacerbating factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.