ArticleAJNR. American journal of neuroradiology2019
Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI.
Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed.
- In-silico solute transport via perivascular networks in the human intracranial space.Nature communications · 2026Article
- Diffusion Tensor Imaging Along the Perivascular Space in Veterans with Remote Mild Traumatic Brain Injuries.Journal of neurotrauma · 2026Article
- Relaxivity of Gadobutrol and Gadoteric Acid in Cerebrospinal Fluid at 3T.Magnetic resonance in medicine · 2026Article
- Vessel-Resolved Mapping of Perivascular Spaces Reveals Hierarchical Neurofluid OrganizationbioRxiv : the preprint server for biology · 2026Article
- Quantitative assessment of flow between cerebrospinal and interstitial fluid compartments in humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Modeling glioma-induced impairments on the glymphatic system.Fluids and barriers of the CNS · 2026Article
- Human brain MRI data of intrathecally injected tracer evolution over 72 hours for data-integrated simulations.Scientific data · 2026Article
- Altered Glymphatic Network in Spinocerebellar Ataxia: a Multimodal MRI Study Within a Structure-Environment-Function Framework.Cerebellum (London, England) · 2026Article
- When blood hits the brain: altered glymphatic and dural lymphatic function after surface bleeds.Acta neurochirurgica · 2026Article
- Day-night variation and age-related differences in gadolinium-based contrast media enhancement in the brain: A T1 mapping study.PloS one · 2026Article
- Impaired glymphatic system for upper limb motor dysfunction in patients with acute ischemic stroke.Quantitative imaging in medicine and surgery · 2025Article
- A 3D non-human primate digital model for pharmacokinetic prediction of intra-cerebrospinal fluid drug neuraxial dispersion.Fluids and barriers of the CNS · 2025Article
- Development of an echo-shifted, multi-echo, gradient-echo sequence for TMagnetic resonance in medicine · 2025Article
- The Therapeutic Potential of Glymphatic System Activity to Reduce the Pathogenic Accumulation of Cytotoxic Proteins in Alzheimer's Disease.International journal of molecular sciences · 2025Review
- Brain fluid physiology in ischaemic stroke; more than just oedema.Fluids and barriers of the CNS · 2025Review
- The Glymphatic System in Cerebrospinal Fluid Dynamics: Clinical Implications, Its Evaluation, and Application to Therapeutics.Neuro-degenerative diseases · 2025Review
- Glymphatic dysfunction in multiple sclerosis and its association with disease pathology and disability.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- Different Glymphatic Kinetics in Spontaneous Intracranial Hypotension.AJNR. American journal of neuroradiology · 2024Article
- The Cerebrovascular Side of Plasticity: Microvascular Architecture across Health and Neurodegenerative and Vascular Diseases.Brain sciences · 2024Review
- Understanding central nervous system fluid networks: Historical perspectives and a revised model for clinical neurofluid imaging.NMR in biomedicine · 2024Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
On the basis of animal models, glymphatic flow disruption is hypothesized to be a factor in the development of Alzheimer's disease. We report the first quantitative study of glymphatic flow in man, combining intrathecal administration of gadobutrol with serial T1 mapping to produce contrast concentration maps up to 3 days postinjection, demonstrating performing a quantitative study using the techniques described feasibility and providing data on pharmacokinetics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.