ArticleAJNR. American journal of neuroradiology2019
Cavum Septum Pellucidum in the General Pediatric Population and Its Relation to Surrounding Brain Structure Volumes, Cognitive Function, and Emotional or Behavioral Problems.
Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Development of a paediatric model of diffuse traumatic brain injury in ferrets.Scientific reports · 2026Article
- Management Considerations for an Isolated Enlarged Cavum Septum Pellucidum: A Case Report.Cureus · 2025Article
- Developmental arrest of astrocyte lineage in Snai2 deletion mice: implication for the intellectual disability in patients with Waardenburg syndrome.Translational psychiatry · 2025Article
- Cavum Septi Pellucidi et Vergae in the Pathogenesis of Prenatally Detected Ventriculomegaly.Current medical imaging · 2025Article
- Enlarged cavum septum pellucidum as a neuroimaging signature of head impact exposure.Brain communications · 2025Article
- Gestational Age-Specific Reference Ranges for Fetal Cavum Septum Pellucidum Width in an Iranian Population : Gestational Age-Specific Reference Ranges for Fetal Cavum Septum Pellucidum Width.Galen medical journal · 2025Article
- Article
- Examining for Cavum Septum Pellucidum and Ventricular Enlargement in Retired Elite-Level Rugby League Players.Frontiers in neurology · 2022Article
- In-depth characterization of neuroradiological findings in a large sample of individuals with autism spectrum disorder and controls.NeuroImage. Clinical · 2022Article
- NANS-CDG: Delineation of the Genetic, Biochemical, and Clinical Spectrum.Frontiers in neurology · 2021Article
- Neuroanatomical Risk Factors for Posttraumatic Stress Disorder in Recent Trauma Survivors.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
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Authors and funding
10 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe cavum septum pellucidum, a cavity filled with CSF, is localized between the 2 lateral ventricles of the brain. The cavum is present in all neonates, but it typically closes within 5 months after birth. In some cases, this closure does not occur and a persistent or enlarged cavum septum pellucidum has been linked, in some studies, to psychiatric disorders. However, the clinical relevance in the general population is unknown. In this study, we examined the relationship between the cavum septum pellucidum and volumes of brain structures, cognitive function, and emotional and behavioral problems in children. MATERIALS AND
methodsThis study was embedded in the Generation R Study, a prospective cohort in Rotterdam, the Netherlands. MR imaging studies of 1070 children, 6-10 years of age, were systematically evaluated for the presence and length of a persistent cavum septum pellucidum. An enlarged cavum septum pellucidum was defined as a cavum length of ≥6 mm. Groups without, with persistent, and with enlarged cavum septi pellucidi were compared for brain structure volumes, nonverbal intelligence, and emotional and behavioral problems.
resultsThe prevalence of cavum septi pellucidi in our sample was 4.6%. Children with an enlarged cavum septum pellucidum had a larger corpus callosum, greater thalamic and total white matter-to-total brain volume ratio, and smaller lateral ventricle volumes. We did not find a relationship between cavum septi pellucidi and cognitive function or emotional and behavioral problems.
conclusionsThe cavum septum pellucidum is a normal structural brain variation without clinical implications in this population-based sample of school-aged children.
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