Evidence map›Paper›PMID 30679191›Full record

ArticleJournal of medical ethics2019

Moral reasons to edit the human genome: picking up from the Nuffield report.

Christopher Gyngell, Hilary Bowman-Smart, Julian Savulescu

Abstract read
In one paragraph

Article in Journal of medical ethics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Gene Editing: Developments, Ethical Considerations, and Future Directions.Journal of community hospital internal medicine perspectives · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
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  11. Review
  12. Article
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  15. Article
  16. The 'serious' factor in germline modification.Journal of medical ethics · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Christopher GyngellDepartment of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Hilary Bowman-SmartMurdoch Children's Research Institute, Melbourne, Victoria, Australia.ORCID 0000-0002-2142-9696
Julian SavulescuMurdoch Children's Research Institute, Melbourne, Victoria, Australia.

Funding

Wellcome Trust 203132
6 · The paper itself

Abstract

In July 2018, the Nuffield Council of Bioethics released its long-awaited report on heritable genome editing (HGE). The Nuffield report was notable for finding that HGE could be morally permissible, even in cases of human enhancement. In this paper, we summarise the findings of the Nuffield Council report, critically examine the guiding principles they endorse and suggest ways in which the guiding principles could be strengthened. While we support the approach taken by the Nuffield Council, we argue that detailed consideration of the moral implications of genome editing yields much stronger conclusions than they draw. Rather than being merely 'morally permissible', many instances of genome editing will be moral imperatives.

Indexed as

Gene EditingAdvisory CommitteesBioethicsEmbryonic Germ CellsEthics CommitteesFemaleGene TargetingGenetic EnhancementGenome, HumanHumansMoralsPregnancyReproductive Techniques, Assistedautonomydistributive justiceenhancementgenetic engineeringinformed consent

Identifiers

PMID30679191
PMCPMC6820147

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.