Evidence map›Paper›PMID 30678888›Full record

ReviewTrends in molecular medicine2019

Remaining Hurdles for Tissue-Engineering the Temporomandibular Joint Disc.

Ryan P Donahue, Jerry C Hu, Kyriacos A Athanasiou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ryan P DonahueDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
Jerry C HuDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
Kyriacos A AthanasiouDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA. Electronic address: athens@uci.edu.
University of California, Irvine · US

Funding

TMJ Disc RegenerationR01DE015038 · NIDCR · UNIVERSITY OF CALIFORNIA-IRVINE · PI ATHANASIOU, KYRIACOS A · 2004 to 2022
$6.1M
NIDCR NIH HHS R01 DE015038
6 · The paper itself

Abstract

The temporomandibular joint (TMJ) disc, a fibrocartilaginous structure between the mandible and temporal bone, is implicated in temporomandibular disorders (TMDs). TMDs symptomatically affect approximately 25% of the population, of which 70% have internal derangement of the disc. Treatments lack efficiency, motivating novel therapies, including tissue-engineering toward TMJ disc regeneration. Recent developments in scaffold-based or scaffold-free approaches, cell sources, and biochemical and mechanical stimulation have resulted in constructs exhibiting native tissue mechanics. Safety and efficacy of tissue-engineered implants have shown promising results in orthotopic animal studies. However, many hurdles need to be overcome in tissue-engineering approaches, and clinical and regulatory pathways. Future studies present an opportunity for clinicians and researchers to work together toward safe and effective clinical trials.

Indexed as

Temporomandibular Joint DiscTissue EngineeringTissue ScaffoldsAnimalsDisease Models, AnimalHumansMotivationTemporomandibular Joint DisordersTranslational Research, Biomedicaltemporomandibular joint disc

Identifiers

PMID30678888
PMCPMC6436948
OpenAlexW2914394986

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.