Evidence map›Paper›PMID 30678836›Full record

ArticleJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia2019

Hyperosmotic intraventricular drug delivery of DV1 in the management of intracranial metastatic breast cancer in a mouse model.

Satish Krishnamurthy, Jie Li, Alexa Bodman, Chaozai Zhang, Yilei Yang, Jing An

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Satish KrishnamurthyDepartment of Neurosurgery, Upstate Medical University, State University of New York (SUNY), 175 Elizabeth Blackwell Street Syracuse, NY 13210, USA. Electronic address: krishnsa@upstate.edu.
Jie LiDepartment of Neurosurgery, Upstate Medical University, State University of New York (SUNY), 175 Elizabeth Blackwell Street Syracuse, NY 13210, USA.
Alexa BodmanDepartment of Neurosurgery, Upstate Medical University, State University of New York (SUNY), 175 Elizabeth Blackwell Street Syracuse, NY 13210, USA.
Chaozai ZhangDepartment of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Yilei YangDepartment of Pharmacology, Upstate Medical University, State University of New York (SUNY), 750 Adams Street, Syracuse, NY 13210, USA.
Jing AnDepartment of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Pharmacology, Upstate Medical University, State University of New York (SUNY), 750 Adams Street, Syracuse, NY 13210, USA.
SUNY Upstate Medical University · USUniversity of California San Diego · US

Funding

STRUCTURES AND INTERACTIONS OF CHEMOKINE RECEPTORSR01GM057761 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI AN, JING, HUANG, ZIWEI · 1998 to 2025
$5.6M
NIGMS NIH HHS R01 GM057761
6 · The paper itself

Abstract

Advances in therapies for breast cancer with cerebral metastases has been slow, despite this being a common diagnosis, due to limited drug delivery by the blood brain barrier. Improvements in drug delivery for brain metastasis to target the metastases and bypass the blood brain barrier are necessary. In our study, we delivered an inhibitor of chemokine receptor 4 by convection enhanced delivery in a hyperosmotic solution to prevent brain metastasis in a mouse model of metastatic breast cancer. We found the inhibitor limited metastatic disease and more interestingly, the hyperosmotic solution targeted tumor tissue allowing for a higher accumulation of the therapy into tumor tissue. This finding has the potential to improve delivery of chemotherapeutic agents to brain metastases.

Indexed as

AnimalsAntineoplastic AgentsBrain NeoplasmsCell Line, TumorDisease Models, AnimalDrug Delivery SystemsFemaleHumansInjections, IntraventricularMammary Neoplasms, ExperimentalMiceMice, NudeOsmolar ConcentrationReceptors, CXCR4Xenograft Model Antitumor AssaysAntineoplastic AgentsReceptors, CXCR4Brain metastasisBreast cancerCXCR4Drug deliveryHyperosmotic therapy

Identifiers

PMID30678836
PMCPMC10158632
OpenAlexW2913210251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.