ArticleVeterinary research2019
Transcriptome analysis unraveled potential mechanisms of resistance to Haemonchus contortus infection in Merino sheep populations bred for parasite resistance.
Article in Veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- RNA-Sequencing in Elucidating Immune Responses to Haemonchus contortus Infection in Small Ruminants: Systematic Review.Parasite immunology · 2025Pooled it
- Sheep Genetic Resistance to Gastrointestinal Nematode Infections: Current Insights from Transcriptomics and Other OMICs Technologies-A Review.Pathogens (Basel, Switzerland) · 2026Review
- Differential gene expression analysis of Dohne Merino sheep naturally infected with Haemonchus contortus.Scientific reports · 2025Article
- Uncovering functional INDELs responsible for splice sites in sheep with different immune profiles naturally exposed to gastrointestinal nematode infection.Scientific reports · 2025Article
- Disruptions in gene interaction networks abolish host susceptibility to Trichostrongylus colubriformis infections in sheep.PLoS neglected tropical diseases · 2025Article
- Escherichia coli is implicated in the development and manifestation of host susceptibility to the roundworm Trichostrongylus colubriformis infections in sheep.Veterinary research · 2025Article
- Complement and Coagulation Cascade Activation Regulates the Early Inflammatory Mechanism of Resistance of Suckling Lambs AgainstPathogens (Basel, Switzerland) · 2025Article
- Recent Advances in the Control of Endoparasites in Ruminants from a Sustainable Perspective.Pathogens (Basel, Switzerland) · 2023Article
- Genome-Wide Analysis of Sheep Artificially or Naturally Infected with Gastrointestinal Nematodes.Genes · 2023Article
- Genome-Wide Association Study forPathogens (Basel, Switzerland) · 2022Article
- Within- and between-Breed Selection Signatures in the Original and Improved Valachian Sheep.Animals : an open access journal from MDPI · 2022Article
- Response of Rambouillet Lambs to an Artificial Gastrointestinal Nematode Infection.Animals : an open access journal from MDPI · 2022Article
- Association analysis and functional annotation of imputed sequence data within genomic regions influencing resistance to gastro-intestinal parasites detected by an LDLA approach in a nucleus flock of Sarda dairy sheep.Genetics, selection, evolution : GSE · 2022Article
- Early Transcriptome Differences Between Pre-Infected and Naïve Kid Goats Infected WithFrontiers in veterinary science · 2022Article
- Between-population differences in constitutive and infection-induced gene expression in threespine stickleback.Molecular ecology · 2021Article
- Genetic × environment variation in sheep lines bred for divergent resistance to strongyle infection.Evolutionary applications · 2021Article
- Identification of Regulatory Functions of LncRNAs Associated WithFrontiers in genetics · 2021Article
- Genome-wide association study to identify genetic loci associated with gastrointestinal nematode resistance in Katahdin sheep.Animal genetics · 2020Article
- Assessment ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2019Article
- Signatures of selection for resistance to Haemonchus contortus in sheep and goats.BMC genomics · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haemonchus contortus is one of the most pathogenic gastrointestinal nematodes in small ruminants. To understand molecular mechanisms underlying host resistance to this parasite, we used RNA-sequencing technology to compare the transcriptomic response of the abomasal tissue, the site of the host-parasite interaction, of Merino sheep bred to be either genetically resistant or susceptible to H. contortus infection. Two different selection flocks, the Haemonchus selection flock (HSF) and the Trichostrongylus selection flock (TSF), and each contains a resistant and susceptible line, were studied. The TSF flock was seemingly more responsive to both primary and repeated infections than HSF. A total of 127 and 726 genes displayed a significant difference in abundance between resistant and susceptible animals in response to a primary infection in HSF and TSF, respectively. Among them, 38 genes were significantly affected by infection in both flocks. Gene ontology (GO) enrichment of the differentially expressed genes identified in this study predicted the likely involvement of extracellular exosomes in the immune response to H. contortus infection. While the resistant lines in HSF and TSF relied on different mechanisms for the development of host resistance, adhesion and diapedesis of both agranulocytes and granulocytes, coagulation and complement cascades, and multiple pathways related to tissue repair likely played critical roles in the process. Our results offered a quantitative snapshot of changes in the host transcriptome induced by H. contortus infection and provided novel insights into molecular mechanisms of host resistance.
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