Evidence map›Paper›PMID 30678691›Full record

ArticleJournal of ovarian research2019

Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma.

Hiroyuki Suzuki, Mitsutake Yano, Mariko Miyazawa, Masaki Miyazawa, Naoki Ogane, Kosei Hasegawa, Hitoshi Tsuda, Masayuki Yoshida, Ryugo Okagaki, Osamu Ishihara and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Hiroyuki SuzukiDepartment of Pathology, Saitama Medical University International Medical Center, Saitama, Japan.
Mitsutake YanoDepartment of Pathology, Saitama Medical University International Medical Center, Saitama, Japan.
Mariko MiyazawaDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa, Japan.
Masaki MiyazawaDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa, Japan.
Naoki OganeDivision of Pathology, Ashigarakami Hospital, Kanagawa, Japan.
Kosei HasegawaDepartment of Gynecologic Oncology, Saitama Medical University International Medical Center, Saitama, Japan.
Hitoshi TsudaDepartment of Basic Pathology, National Defense Medical College, Saitama, Japan.
Masayuki YoshidaDepartment of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
Ryugo OkagakiDepartment of Obstetrics and Gynecology, Saitama Medical University Hospital, Saitama, Japan.
Osamu IshiharaDepartment of Obstetrics and Gynecology, Saitama Medical University Hospital, Saitama, Japan.
Masanori YasudaDepartment of Pathology, Saitama Medical University International Medical Center, Saitama, Japan. m_yasuda@saitama-med.ac.jp.
Saitama International Medical Center · JPSaitama Medical University · JPSaitama Medical University Hospital · JPTokai University · JPNational Defense Medical College · JPTokyo National Hospital · JP

Funding

Grants-in-Aid from the Ministry of Education, Science, Sports and Culture of Japan 15K08355Grants-in-Aid from the Ministry of Education, Science, Sports and Culture of Japan 18K06997Hidaka Research Projects in the Saitama Medical University 30-D-1-3
6 · The paper itself

Abstract

backgroundOvarian clear cell carcinoma (OCCC) is the second most common ovarian cancer after serous carcinoma in Japan. OCCC has a more unfavorable clinical outcome due to a poor response to platinum-based chemotherapy, compared with serous carcinoma. Hypoxia inducible factor-1α (HIF-1α) is a key regulator of cellular response to hypoxia and plays an important role in tumor growth, and HIF-1α gene single-nucleotide polymorphisms (SNPs) adversely affect the outcome in some cancers. Herein, we investigated the association of the HIF-1α gene SPNs with clinical outcome in OCCCs. Eighty-nine patients with OCCC were recruited in whom pathological diagnosis was confirmed with surgically resected specimen.

resultsThe SNPs of C1772T and G1790A in the HIF-1α gene occurred in 23.6 and 3.3% of the patients, respectively. In the univariate analysis, overall survival was associated with stage and surgical residual tumor but not with the SNPs C1772T, G1790A, C1772T and/or G1790A. In the multivariate survival analysis, a significant association was observed between outcome and FIGO stage and/or surgical residual tumor; however, no association was obtained between HIF-1α gene SNPs and these factors.

conclusionIn conclusion, unlike the other cancers in which HIF-1α gene SNPs were demonstrated to be associated with the outcome, OCCC prognosis may not be affected by HIF-1α gene SNPs. Further studies need to be performed to clarify the association of HIF-1α expression with the unfavorable prognosis in OCCCs, in terms of transcriptional/translational activity, nuclear translocation of the protein, and protein degradation.

Indexed as

Adenocarcinoma, Clear CellAdultAgedFemaleGenotypeHumansHypoxia-Inducible Factor 1, alpha SubunitKaplan-Meier EstimateMiddle AgedNeoplasm StagingOvarian NeoplasmsPolymorphism, Single NucleotidePrognosisHypoxia-Inducible Factor 1, alpha SubunitHypoxia-inducible factor-1α (HIF-1α)Ovarian clear cell carcinomaPrognosisSingle-nucleotide polymorphisms (SNPs)

Identifiers

PMID30678691
PMCPMC6345011
OpenAlexW2921695967

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.