ArticleBMC cardiovascular disorders2019
Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study.
Article in BMC cardiovascular disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01067703 (Remote Ischaemic Preconditioning for Heart Surgery), which is not on this map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Remote Ischaemic Preconditioning for Heart Surgery
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Dissecting the genetic and proteomic risk factors for delirium.Nature aging · 2026Pooled it
- Genome-wide association study of hospitalized patients and acute kidney injury.Kidney international · 2024Pooled it
- Limited clinical utility for GWAS or polygenic risk score for postoperative acute kidney injury in non-cardiac surgery in European-ancestry patients.BMC nephrology · 2022Pooled it
- The complex interaction of genetics and delirium: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2021Pooled it
- The genetic architecture of postoperative delirium after major surgery and its relationship with nonpostoperative neurocognitive conditions: A genome-wide association study.PLoS medicine · 2026Article
- Pharmacological strategies for myocardial protection in cardiac surgery: current science and the emerging role of multi-omics and artificial intelligence.Frontiers in cardiovascular medicine · 2026Review
- Identification of Key Genes Associated with Endoplasmic Reticulum Stress in Calcium Oxalate Kidney Stones.Genes · 2025Article
- Genetic Variation and Sex-Based Differences: Current Considerations for Anesthetic Management.Current issues in molecular biology · 2025Review
- Effect of remote ischemic preconditioning on perioperative neurocognitive disorder in elderly patients undergoing major surgery and associated genetic variant analysis: a randomized clinical trial.Perioperative medicine (London, England) · 2025Article
- Knockdown of Mmu-circ-0001380 Attenuates Myocardial Ischemia/Reperfusion Injury via Modulating miR-106b-5p/Phlpp2 Axis.Journal of cardiovascular translational research · 2023Article
- Genome-wide association study of dilated cardiomyopathy-induced heart failure associated with renal insufficiency in a Chinese population.BMC cardiovascular disorders · 2023Article
- Genetic predisposition may not improve prediction of cardiac surgery-associated acute kidney injury.Frontiers in genetics · 2023Article
- Identification of risk factors for infection after mitral valve surgery through machine learning approaches.Frontiers in cardiovascular medicine · 2023Article
- Application of Multiple Omics to Understand Postoperative Delirium Pathophysiology in Humans.Gerontology · 2023Review
- Alarmins as a Possible Target of Future Therapies for Atrial Fibrillation.International journal of molecular sciences · 2022Review
- DUSP4 alleviates LPS-induced chondrocyte injury in knee osteoarthritis via the MAPK signaling pathway.Experimental and therapeutic medicine · 2021Article
- Association between genetic variants of the cholinergic system and postoperative delirium and cognitive dysfunction in elderly patients.BMC medical genomics · 2021Observational
- Genetic Susceptibility to Acute Kidney Injury.Journal of clinical medicine · 2021Review
- Potential Value of TNF-α (-376 G/A) Polymorphism and Cystatin C (CysC) in the Diagnosis of Sepsis Associated Acute Kidney Injury (S-AK I) and Prediction of Mortality in Critically Ill patients.Frontiers in molecular biosciences · 2021Article
- Machine Learning for the Prediction of Complications in Patients After Mitral Valve Surgery.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
43 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.
methodsWe conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.
resultsA total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10
conclusionsWe identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery.
trial registrationThe study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010.
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