ArticleBMC infectious diseases2019
Consecutive antibiotic use in the outpatient setting: an extensive, longitudinal descriptive analysis of antibiotic dispensing data in the Netherlands.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Overview of Methods for Assessing Antimicrobial Use in Outpatient Settings in High-Income Countries: A Narrative Review.Antibiotics (Basel, Switzerland) · 2025Review
- Discrepancy between antibiotic pack sizes and guideline recommendations: a real-world analysis based on claims data.Infection · 2025Observational
- Antibiotic Utilization Among People With Multiple Sclerosis in the Netherlands, 2018-2020.Pharmacoepidemiology and drug safety · 2024Article
- Article
- Nitrofurantoin failure in males with an uncomplicated urinary tract infection: a primary care observational cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Observational
- The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS.bioRxiv : the preprint server for biology · 2023Article
- Patterns of biologic and targeted-synthetic disease-modifying antirheumatic drug use in rheumatoid arthritis in Australia.Rheumatology (Oxford, England) · 2022Article
- Increased prescription rate of anti-infective agents after diagnosis of myelodysplastic syndromes.EJHaem · 2022Article
- The Decline in Outpatient Antibiotic Use.Deutsches Arzteblatt international · 2020Article
- Marked reductions in outpatient antibiotic prescriptions for children and adolescents - a population-based study covering 83% of the paediatric population, Germany, 2010 to 2018.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
- Nitrofurantoin Failure in Elderly Men: A Retrospective Observational Study.Antibiotics (Basel, Switzerland) · 2020Article
- Antimicrobial Stewardship: Fighting Antimicrobial Resistance and Protecting Global Public Health.Infection and drug resistance · 2020Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTaking consecutive antibiotic use into account is of importance to obtain insight in treatment within disease episodes, use of 2nd- and 3rd-choice antibiotics, therapy failure and/or side effects. Nevertheless, studies dealing with consecutive antibiotic use are scarce. We aimed at evaluating switch patterns in antibiotic use in the outpatient setting in the Netherlands.
methodsOutpatient antibiotic dispensing data was processed to antibiotic treatment episodes consisting of single prescriptions or consecutive prescriptions (2006 to 2014). Consecutive prescriptions were categorised into prolongations and switches. Switches were further analysed to obtain antibiotic switch percentages and trends over time. Outcomes were compared with recommendations of Dutch guidelines.
resultsA total of 43,179,867 antibiotic prescriptions were included in the analysis, consisting of single prescriptions (95%), prolongations (2%) and switches (3%). The highest switch percentages were found for trimethoprim (7.6%) and nitrofurantoin (5.4%). For fosfomycin, ciprofloxacin, flucloxacillin and trimethoprim we found the highest yearly increase in switching. Amoxicillin/clavulanic acid was most often used as second antibiotic in a switch. A surprisingly high number of 2nd- and 3rd-choice antibiotics are prescribed as first antibiotic in a treatment.
conclusionsAlthough the actual reason for a switch is unknown, switch patterns can reveal problems concerning treatment failure and guideline adherence. In general, switch percentages of antibiotics in the Netherlands are low. The data contributes to the knowledge regarding antibiotic switch patterns in the outpatient setting.
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