Evidence map›Paper›PMID 30678376›Full record

ArticleSensors (Basel, Switzerland)2019

Electrochemical DNA Sensors with Layered Polyaniline-DNA Coating for Detection of Specific DNA Interactions.

Tatjana Kulikova, Anna Porfireva, Gennady Evtugyn, Tibor Hianik

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tatjana KulikovaA.M. Butlerov' Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, Kazan 420008, Russia. wefy2009@yandex.ru.
Anna PorfirevaA.M. Butlerov' Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, Kazan 420008, Russia. porfireva-a@inbox.ru.
Gennady EvtugynA.M. Butlerov' Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, Kazan 420008, Russia. gennady.evtugyn@kpfu.ru.ORCID 0000-0002-4694-7836
Tibor HianikDepartment of Nuclear Physics and Biophysics, Comenius University, Mlynska dolina F1, 842 48 Bratislava, Slovakia. tibor.hianik@fmph.uniba.sk.ORCID 0000-0002-5906-0548

Funding

Agentúra na Podporu Výskumu a Vývoja APVV-14-0267Russian Science Foundation 17-73-20024
6 · The paper itself

Abstract

A DNA sensor has been proposed on the platform of glassy carbon electrode modified with native DNA implemented between two electropolymerized layers of polyaniline. The surface layer was assembled by consecutive stages of potentiodynamic electrolysis, DNA drop casting, and second electrolysis, which was required for capsulation of the DNA molecules and prevented their leaching into the solution. Surface layer assembling was controlled by cyclic voltammetry, electrochemical impedance spectroscopy, atomic force, and scanning electron microscopy. For doxorubicin measurement, the DNA sensor was first incubated in the Methylene blue solution that amplified signal due to DNA intercalation and competition with the doxorubicin molecules for the DNA binding sites. The charge transfer resistance of the inner layer interface decreased with the doxorubicin concentration in the range from 1.0 pM to 0.1 μM (LOD 0.6 pM). The DNA sensor was tested for the analysis of spiked artificial urine samples and showed satisfactory recovery in concentration range of 0.05⁻10 μM. The DNA sensor developed can find application in testing of antitumor drugs and some other DNA damaging factors.

Indexed as

Aniline CompoundsBiosensing TechniquesDielectric SpectroscopyDNADoxorubicinElectrochemical TechniquesAniline CompoundsDNADoxorubicinpolyanilineDNA intercalatordoxorubicinelectrochemical DNA sensorelectrochemical impedance spectroscopyelectropolymerizationpolyaniline

Identifiers

PMID30678376
PMCPMC6387217

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.