Evidence map›Paper›PMID 30678364›Full record

ArticleInternational journal of molecular sciences2019

Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer's Disease.

Kamila Czarnecka, Małgorzata Girek, Paweł Kręcisz, Robert Skibiński, Kamil Łątka, Jakub Jończyk, Marek Bajda, Jacek Kabziński, Ireneusz Majsterek, Piotr Szymczyk and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kamila CzarneckaDepartment of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90d-151 Lodz, Poland. kamila.czarnecka@umed.lodz.pl.
Małgorzata GirekDepartment of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90d-151 Lodz, Poland. malgorzata.girek@stud.umed.lodz.pl.
Paweł KręciszDepartment of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90d-151 Lodz, Poland. pawel.krecisz@stud.umed.lodz.pl.
Robert SkibińskiDepartment of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland. robertskibinski@umlub.pl.ORCID 0000-0001-8429-7515
Kamil ŁątkaDepartment of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland. kamil.latka@doctoral.uj.edu.pl.
Jakub JończykDepartment of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland. jakub.jonczyk@doctoral.uj.edu.pl.ORCID 0000-0002-9731-908X
Marek BajdaDepartment of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland. marek.bajda@uj.edu.pl.ORCID 0000-0001-6032-0354
Jacek KabzińskiDepartment of Clinical Chemistry and Biochemistry, Medical University of Lodz, Pl. Hallera 1, 90-647 Lodz, Poland. jacek.kabzinski@umed.lodz.pl.
Ireneusz MajsterekDepartment of Clinical Chemistry and Biochemistry, Medical University of Lodz, Pl. Hallera 1, 90-647 Lodz, Poland. ireneusz.majsterek@umed.lodz.pl.
Piotr SzymczykDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, Poland. piotr.szymczyk@umed.lodz.pl.ORCID 0000-0002-7688-4717
Paweł SzymańskiDepartment of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90d-151 Lodz, Poland. pawel.szymanski@umed.lodz.pl.ORCID 0000-0003-3438-7509

Funding

Narodowe Centrum Nauki 2015/19/B/NZ7/02847Uniwersytet Jagielloński Collegium Medicum K/DSC/002860Uniwersytet Medyczny w Lodzi 502-03/3-015-01/502-34-092
6 · The paper itself

Abstract

Here we report the two-step synthesis of 8 new cyclopentaquinoline derivatives as modifications of the tetrahydroacridine structure. Next, the biological assessment of each of them was performed. Based on the obtained results we identified 6-chloro-

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCell LineCell Line, TumorCholinesterase InhibitorsHumansMolecular Docking SimulationNeuroprotective AgentsProtein BindingQuinolinesAmyloid beta-PeptidesCholinesterase InhibitorsNeuroprotective AgentsQuinolinesacetylcholinesterase inhibitorsAlzheimer’s diseasebeta amyloidmolecular modelingyeast three-hybrid technology (Y3H) test

Identifiers

PMID30678364
PMCPMC6386991

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.