Evidence map›Paper›PMID 30678324›Full record

ReviewJournal of fungi (Basel, Switzerland)2019

Invasive Candidiasis in Infants and Children: Recent Advances in Epidemiology, Diagnosis, and Treatment.

Thomas J Walsh, Aspasia Katragkou, Tempe Chen, Christine M Salvatore, Emmanuel Roilides

Open access · goldAbstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 57 citations in OpenAlex.

  1. Observational
  2. Article
  3. Fungal Infections in Pediatric Patients With Hematologic Malignancies and Stem Cell Transplantation: Impact on the Upper and Lower Respiratory Systems.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Review
  4. Article
  5. PediatricJournal of fungi (Basel, Switzerland) · 2025
    Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Molecular Diagnosis of Yeast Infections.Current fungal infection reports · 2021
    Review
  15. Changes in the Ultrastructure ofMicroorganisms · 2020
    Article
  16. Article
  17. Article
  18. Clinical and epidemiological aspects of Candidemia in eight medical centers in the state of Parana, Brazil: Parana Candidemia Network.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Thomas J WalshDepartments of Medicine, Pediatrics, and Microbiology & immunology, Weill Cornell Medicine of Cornell University and New York Presbyterian Hospital, New York, NY 10065, USA. thw2003@med.cornell.edu.
Aspasia KatragkouDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Nationwide Children's Hospital and The Ohio State University School of Medicine, Columbus, OH 43205, USA. Aspasia.Katragkou@nationwidechildrens.org.
Tempe ChenPediatric Infectious Diseases, Department of Pediatrics, Miller Children's Hospital and University of California Irvine, Long Beach, CA 90806, USA. TChen@memorialcare.org.
Christine M SalvatoreDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Weill Cornell Medicine of Cornell University and New York Presbyterian Hospital, New York, NY 10065, USA. chs2032@med.cornell.edu.
Emmanuel RoilidesInfectious Diseases Section, 3rd Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences and Hippokration General Hospital, 54642 Thessaloniki, Greece. roilides@med.auth.gr.ORCID 0000-0002-0202-364X
NewYork–Presbyterian Hospital · USHippocration General Hospital · GRNationwide Children's Hospital · USUniversity of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper reviews recent advances in three selected areas of pediatric invasive candidiasis: epidemiology, diagnosis, and treatment. Although the epidemiological trends of pediatric invasive candidiasis illustrate a declining incidence, this infection still carries a heavy burden of mortality and morbidity that warrants a high index of clinical suspicion, the need for rapid diagnostic systems, and the early initiation of antifungal therapy. The development of non-culture-based technologies, such as the T2Candida system and (1→3)-β-d-glucan detection assay, offers the potential for early laboratory detection of candidemia and CNS candidiasis, respectively. Among the complications of disseminated candidiasis in infants and children, hematogenous disseminated

Indexed as

(1→3)-β-d-glucananidulafunginCandida meningoencephalitiscandidemialiposomal amphotericin BmicafunginPCRT2Candida

Identifiers

PMID30678324
PMCPMC6463055
OpenAlexW2913554862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.