ArticleInternational journal of molecular sciences2019
The Chemical Characterization of Eleutherococcus senticosus and Ci-wu-jia Tea using UHPLC-UV-QTOF/MS.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
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- Chemical Composition and In Vitro Biological Activity of the Polar and Non-Polar Fractions Obtained from the Roots ofInternational journal of molecular sciences · 2025Article
- Review
- Analysis of Variations in the Flavonoid Profiles ofPlants (Basel, Switzerland) · 2025Article
- Study on the protective effects and mechanisms of eleutherococcus senticosus on korsakoff syndrome.Frontiers in neuroscience · 2025Review
- Comprehensive profiling of phenolic compounds and triterpenoid saponins from Acanthopanax senticosus and their antioxidant, α-glucosidase inhibitory activities.Scientific reports · 2024Article
- A Phyto-mycotherapeutic Supplement, NamelyInternational journal of molecular sciences · 2024Article
- Use of a rat model to characterize 35 arterial pulse wave parameters in a comparative study of isoflurane and Zoletil/xylazine anesthesia and the effect of Acanthopanax senticosus extract.Animal models and experimental medicine · 2023Article
- Study on Extraction and Purification ofMolecules (Basel, Switzerland) · 2023Article
- Acanthopanax senticosus extract alleviates radiation-induced learning and memory impairment based on neurotransmitter-gut microbiota communication.CNS neuroscience & therapeutics · 2023Article
- Article
- Quality Consistency of Herbal Products: Chemical Evaluation.Progress in the chemistry of organic natural products · 2023Article
- Antioxidant Activity ofMolecules (Basel, Switzerland) · 2022Article
- Exploring potential mechanism of ciwujia tablets for insomnia by UPLC-Q-TOF-MS/MS, network pharmacology, and experimental validation.Frontiers in pharmacology · 2022Article
- Adsorption and Desorption Characteristics of Total Flavonoids fromMolecules (Basel, Switzerland) · 2021Article
- Pharmacognostic Evaluation and HPLC-PDA and HS-SPME/GC-MS Metabolomic Profiling ofMolecules (Basel, Switzerland) · 2021Article
- Is Our Natural Food Our Homeostasis? Array of a Thousand Effect-Directed Profiles of 68 Herbs and Spices.Frontiers in pharmacology · 2021Article
- Chemical Authentication of Botanical Ingredients: A Review of Commercial Herbal Products.Frontiers in pharmacology · 2021Review
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Eleutherococcus senticosus Maxim. belongs to the Araliaceae family. Phytochemical studies reveal that E. senticosus leaves contain triterpene glycosides along with organic acid derivatives and flavonoid compounds. It is believed that E. senticosus is similar to ginseng because they come from same family and both contain triterpene saponins. E. senticosus leaves have been developed as a functional beverage called ci-wu-jia tea in recent years. Triterpene glycosides are difficult to identify by ultraviolet (UV) detection and contents of these compounds are low in E. senticosus leaves. In this study, a sensitive ultra-high performance liquid chromatographic (UHPLC) method combining UV and tandem mass spectrometry (MS/MS) was developed to characterize the triterpene glycosides from E. senticosus leaves and related commercial products. Fragmentation patterns of three sub-groups of triterpene glycosides in E. senticosus leaves were investigated. Additionally, fragmentation pathways and UV characteristics of organic acid derivatives and flavonoids were also characterized. A compound screening library, including 241 compounds reported in the literature, was created and used to confirm the compounds in the samples. In this study, a total of 24 samples, including 13 plant samples of E. senticosus and 11 ci-wu-jia tea products, were analyzed. Out of the 11 commercial products, three products were discovered to contain green tea (Camellia sinensis) that was considered to be an adulterant since it was not an ingredient on the labels. The developed UHPLC-UV-MS/MS analytical method combined with the UNIFI processing method can simultaneously characterize organic acid derivatives, flavonoids, and triterpene saponins from E. senticosus. It provides a simple and sensitive way to perform quality control of E. senticosus and related ci-wu-jia tea products.
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