Evidence map›Paper›PMID 30678297›Full record

ReviewMolecules (Basel, Switzerland)2019

Medium Chain Carboxylic Acids from Complex Organic Feedstocks by Mixed Culture Fermentation.

Vicky De Groof, Marta Coma, Tom Arnot, David J Leak, Ana B Lanham

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Article
  3. Molecular Chain Elongation Mechanism for n-Caproate Biosynthesis by Megasphaera Hexanoica.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. A specific HFrontiers in bioengineering and biotechnology · 2023
    Article
  10. Butanol as a major product during ethanol and acetate chain elongation.Frontiers in bioengineering and biotechnology · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Hydrogen as a Co-electron Donor for Chain Elongation With Complex Communities.Frontiers in bioengineering and biotechnology · 2021
    Article
  17. Article
  18. Bioaugmented Mixed Culture byFrontiers in microbiology · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vicky De GroofEPSRC Centre for Doctoral Training in Sustainable Chemical Technologies, University of Bath, Claverton Down, Bath BA2 7AY, UK. V.De.Groof@bath.ac.uk.
Marta ComaCentre for Sustainable Chemical Technologies (CSCT), University of Bath, Claverton Down, Bath BA2 7AY, UK. M.Coma@bath.ac.uk.ORCID 0000-0002-8434-7778
Tom ArnotDepartment of Chemical Engineering, University of Bath, Claverton Down, Bath BA2 7AY, UK. T.C.Arnot@bath.ac.uk.
David J LeakCentre for Sustainable Chemical Technologies (CSCT), University of Bath, Claverton Down, Bath BA2 7AY, UK. D.J.Leak@bath.ac.uk.
Ana B LanhamDepartment of Chemical Engineering, University of Bath, Claverton Down, Bath BA2 7AY, UK. a.lanham@bath.ac.uk.

Funding

Engineering and Physical Sciences Research Council EP/L016354/European Commission H2020-MSCA-CO-FUND, No 665992
6 · The paper itself

Abstract

Environmental pressures caused by population growth and consumerism require the development of resource recovery from waste, hence a circular economy approach. The production of chemicals and fuels from organic waste using mixed microbial cultures (MMC) has become promising. MMC use the synergy of bio-catalytic activities from different microorganisms to transform complex organic feedstock, such as by-products from food production and food waste. In the absence of oxygen, the feedstock can be converted into biogas through the established anaerobic digestion (AD) approach. The potential of MMC has shifted to production of intermediate AD compounds as precursors for renewable chemicals. A particular set of anaerobic pathways in MMC fermentation, known as chain elongation, can occur under specific conditions producing medium chain carboxylic acids (MCCAs) with higher value than biogas and broader applicability. This review introduces the chain elongation pathway and other bio-reactions occurring during MMC fermentation. We present an overview of the complex feedstocks used, and pinpoint the main operational parameters for MCCAs production such as temperature, pH, loading rates, inoculum, head space composition, and reactor design. The review evaluates the key findings of MCCA production using MMC, and concludes by identifying critical research targets to drive forward this promising technology as a valorisation method for complex organic waste.

Indexed as

FermentationBiofilmsBioreactorsBiotransformationCarboxylic AcidsEnvironmentHydrogen-Ion ConcentrationMetabolic Networks and PathwaysModels, ChemicalThermodynamicsWaste ProductsCarboxylic AcidsWaste Productsanaerobiccarboxylate platformchain elongationcircular economymedium chain carboxylic acidmixed microbial cultureorganic wasteresource recoverywaste valorisation

Identifiers

PMID30678297
PMCPMC6384945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.