Evidence map›Paper›PMID 30678296›Full record

ReviewPharmaceutics2019

Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery.

Santiago Grijalvo, Gustavo Puras, Jon Zárate, Myriam Sainz-Ramos, Nuseibah A L Qtaish, Tania López, Mohamed Mashal, Noha Attia, David Díaz, Ramon Pons and 3 more

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Santiago GrijalvoInstitute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, E-08034 Barcelona, Spain. sgrgma@cid.csic.es.
Gustavo PurasNetworking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-08034 Barcelona, E-01006 Vitoria-Gasteiz and E-03202 Elche, Spain. gustavo.puras@ehu.eus.
Jon ZárateNetworking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-08034 Barcelona, E-01006 Vitoria-Gasteiz and E-03202 Elche, Spain. jon.zarate@ehu.eus.ORCID 0000-0003-1999-057X
Myriam Sainz-RamosNetworking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-08034 Barcelona, E-01006 Vitoria-Gasteiz and E-03202 Elche, Spain. miriam.sainz@ehu.eus.
Nuseibah A L QtaishNetworking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-08034 Barcelona, E-01006 Vitoria-Gasteiz and E-03202 Elche, Spain. nusaiba.qtaish@gmail.com.
Tania LópezNetworking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-08034 Barcelona, E-01006 Vitoria-Gasteiz and E-03202 Elche, Spain. tblopez01@gmail.com.ORCID 0000-0001-5029-6549
Mohamed MashalNanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain. mahmed001@ikasle.ehu.es.
Noha AttiaNanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain. noha.attia@alexmed.edu.eg.
David DíazInstituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain. d.diaz.diaz@ipna.csic.es.
Ramon PonsInstitute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, E-08034 Barcelona, Spain. ramon.pons@iqac.csic.es.
Eduardo FernándezNetworking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-08034 Barcelona, E-01006 Vitoria-Gasteiz and E-03202 Elche, Spain. e.fernandez@umh.es.
José Luis PedrazNetworking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-08034 Barcelona, E-01006 Vitoria-Gasteiz and E-03202 Elche, Spain. joseluis.pedraz@ehu.eus.
Ramon EritjaInstitute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, E-08034 Barcelona, Spain. recgma@cid.csic.es.ORCID 0000-0001-5383-9334

Funding

Friendly Voices ProgramK07CA088948 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ASHFORD, ROWELL S · 2001 to 2006
$651k
PROGNOSTIC BIOMARKERS FOR HEAD AND NECK CANCERR01CA084415 · NCI · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI ANG, K KIAN · 2000 to 2002
$562k
SYNTHESIS OF RNA CANCER VACCINESR43CA069967 · NCI · AMBION, INC. · PI PASLOSKE, BRITTAN L · 1996 to 1996
–
SYNTHESIS OF RNA CANCER VACCINESR44CA069967 · NCI · AMBION, INC. · PI PASLOSKE, BRITTAN L · 1997 to 1998
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Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina CB06_01_0019Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina CB06_01_1028Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina CB06_01_1053Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya 2017/SGR/114Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya 2017/SGR/670Ikerbasque, Basque Foundation for Science CGIC10/172Ministerio de Ciencia e Innovación CTQ2017-84415-RMinisterio de Ciencia e Innovación CTQ2017-88948-PMinisterio de Ciencia y Tecnología MAT2015-69967-C3-1R
6 · The paper itself

Abstract

Cationic niosomes have become important non-viral vehicles for transporting a good number of small drug molecules and macromolecules. Growing interest shown by these colloidal nanoparticles in therapy is determined by their structural similarities to liposomes. Cationic niosomes are usually obtained from the self-assembly of non-ionic surfactant molecules. This process can be governed not only by the nature of such surfactants but also by others factors like the presence of additives, formulation preparation and properties of the encapsulated hydrophobic or hydrophilic molecules. This review is aimed at providing recent information for using cationic niosomes for gene delivery purposes with particular emphasis on improving the transportation of antisense oligonucleotides (ASOs), small interference RNAs (siRNAs), aptamers and plasmids (pDNA).

Indexed as

antisense oligonucleotidesaptamerscationic lipidscationic niosomesgene deliveryplasmidssmall interference RNAtherapy

Identifiers

PMID30678296
PMCPMC6409589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.