Evidence map›Paper›PMID 30678264›Full record

ArticleNutrients2019

Vegetable Nitrate Intakes Are Associated with Reduced Self-Reported Cardiovascular-Related Complications within a Representative Sample of Middle-Aged Australian Women, Prospectively Followed up for 15 Years.

Jacklyn K Jackson, Amanda J Patterson, Lesley K MacDonald-Wicks, Peta M Forder, Lauren C Blekkenhorst, Catherine P Bondonno, Jonathan M Hodgson, Natalie C Ward, Carl Holder, Christopher Oldmeadow and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Nitrate in groundwater and agricultural products: intake and risk assessment in northeastern Iran.Environmental science and pollution research international · 2022
    Article
  7. Article
  8. Review
  9. Article
  10. Determination of the [Molecules (Basel, Switzerland) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jacklyn K JacksonFaculty of Health and Medicine, School of Health Sciences, Department of Nutrition and Dietetics, University of Newcastle, Callaghan, NSW 2308, Australia. Jacklyn.Jackson@uon.edu.au.ORCID 0000-0001-7633-0418
Amanda J PattersonFaculty of Health and Medicine, School of Health Sciences, Department of Nutrition and Dietetics, University of Newcastle, Callaghan, NSW 2308, Australia. Amanda.Patterson@newcastle.edu.au.ORCID 0000-0002-1868-7918
Lesley K MacDonald-WicksFaculty of Health and Medicine, School of Health Sciences, Department of Nutrition and Dietetics, University of Newcastle, Callaghan, NSW 2308, Australia. Lesley.Wicks@newcastle.edu.au.
Peta M ForderResearch Centre for Generational Health and Ageing, Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW 2305, Australia. Peta.Forder@newcastle.edu.au.ORCID 0000-0003-0591-471X
Lauren C BlekkenhorstSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6207, Australia. l.blekkenhorst@ecu.edu.au.ORCID 0000-0003-1561-9052
Catherine P BondonnoSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6207, Australia. c.bondonno@ecu.edu.au.
Jonathan M HodgsonSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6207, Australia. jonathan.hodgson@ecu.edu.au.
Natalie C WardMedical School, Royal Perth Hospital Unit, University of Western Australia, Perth, WA 6009, Australia. Natalie.Ward@curtin.edu.au.ORCID 0000-0002-6042-437X
Carl HolderClinical Research Design, Information Technology and Statistical Support Unit, Hunter Medical Research Institute, New Lambton, NSW 2305, Australia. Carl.Holder@hmri.org.au.ORCID 0000-0002-5364-9773
Christopher OldmeadowClinical Research Design, Information Technology and Statistical Support Unit, Hunter Medical Research Institute, New Lambton, NSW 2305, Australia. Christopher.Oldmeadow@hmri.org.au.
Julie E BylesResearch Centre for Generational Health and Ageing, Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW 2305, Australia. Julie.Byles@newcastle.edu.au.
Mark A McEvoyFaculty of Health and Medicine, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW 2305, Australia. Mark.Mcevoy@newcastle.edu.au.
Hunter Medical Research Institute · AUEdith Cowan University · AUUniversity of Newcastle Australia · AUThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitric oxide (NO) facilitates anti-atherosclerotic effects. Vegetables are a major source of dietary nitrate. Experimental data indicates that dietary nitrate can significantly reduce major risk factors for atherosclerosis and subsequent cardiovascular disease (CVD), as nitrate can be metabolized to produce NO via the nitrate-nitrite-NO pathway. The purpose of this study was to prospectively investigate the association between habitual dietary nitrate intakes and the incidence of self-reported CVD-related complications within a representative sample of middle-aged Australian women (1946⁻1951 cohort of the Australian Longitudinal Study on Women's Health). Women free from disease at baseline who had completed the food frequency questionnaire data were included. Generalized estimating equations were used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) across quartiles for nitrate intakes. Of the 5324 women included for analysis, there were 1951 new cases of CVD-related complications over 15-years of follow-up. Women reporting higher total dietary nitrate intakes (Q4 > 78.2 mg/day) and vegetable nitrate intakes (Q4 > 64.4 mg/day) were 25% and 27% reduced risk of developing CVD-related complications respectively, compared with women reporting low total (Q1 < 45.5 mg/day) and vegetable nitrate intakes (Q1 < 34.8 mg/day). Our findings were consistent with other observational data indicating that dietary nitrate may explain some of the cardiovascular benefits of vegetable consumption.

Indexed as

AustraliaCardiovascular DiseasesDietFemaleHumansMiddle AgedNitratesOdds RatioSelf ReportVegetablesNitratescardiovascular diseasedietary nitrateheart diseasehypertensionnon-vegetable nitratestrokethrombosisvegetable nitrate

Identifiers

PMID30678264
PMCPMC6412377
OpenAlexW2914345925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.