Evidence map›Paper›PMID 30678250›Full record

ArticleJournal of clinical medicine2019

Circulating MiRNA-195-5p and -451a in Transient and Acute Ischemic Stroke Patients in an Emergency Department.

Mauro Giordano, Tiziana Ciarambino, Michele D'Amico, Maria Consiglia Trotta, Alessandra Marinella Di Sette, Raffaele Marfella, Lorenzo Malatino, Giuseppe Paolisso, Luigi Elio Adinolfi

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Serum vascular endothelial growth factor (VEGF) levels in ischemic stroke patients: a systematic review and meta-analysis of case-control studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Pooled it
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  13. Liquid Biopsy for Cancer Cachexia: Focus on Muscle-Derived microRNAs.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mauro GiordanoDepartment of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", 80138 Naples, Italy. mauro.giordano@unicampania.it.
Tiziana CiarambinoDepartment of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", 80138 Naples, Italy. Tiziana.ciarambino@gmail.com.
Michele D'AmicoDepartment of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", 80138 Naples, Italy. michele.damico@unicampania.it.
Maria Consiglia TrottaDepartment of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", 80138 Naples, Italy. mariaconsiglia.trotta2@unicampania.it.
Alessandra Marinella Di SetteDepartment of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", 80138 Naples, Italy. alessandra.marinella@inwind.it.
Raffaele MarfellaDepartment of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", 80138 Naples, Italy. raffaele.marfella@unicampania.it.
Lorenzo MalatinoDepartment of Medicine, Section of Hypertension and Cardio-Renal Diseases, University of Catania, 95126 Catania, Italy. malatino@unict.it.
Giuseppe PaolissoDepartment of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", 80138 Naples, Italy. giuseppe.paolisso@unicampania.it.
Luigi Elio AdinolfiDepartment of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", 80138 Naples, Italy. luigielio.adinolfi@unicampania.it.
University of Campania "Luigi Vanvitelli" · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have evaluated circulating miRNAs (-195-5p and -451a) in subjects with acute ischemic stroke (AIS) and in patients with transient ischemic attack (TIA). In this study, 18 subjects with AIS and 18 patients with TIA were enrolled and examined at admission (T0) and at 24 h and 48 h after admission, and compared to 20 controls (C). At T0, circulating miRNA-195-5p and -451a were significantly upregulated in both AIS and TIA patients, compared to C. We also observed a progressive reduction of circulating miRNA levels at 24 h and 48 h in both AIS and TIA patients. Hypoxia inducible factor 1alpha (HIF-1α) serum level was significantly increased at T0, in both AIS and TIA patients, in comparison to C (both

Indexed as

acute ischemic strokeemergencymiRNAtransient ischemic attack

Identifiers

PMID30678250
PMCPMC6406765
OpenAlexW2912085356

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.