ArticleSensors (Basel, Switzerland)2019
A Point-of-Care Device for Molecular Diagnosis Based on CMOS SPAD Detectors with Integrated Microfluidics.
Article in Sensors (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Reusable 3D-printed microfluidic-on-fabric with modular electrodes for point-of-care NaAnalytical and bioanalytical chemistry · 2026Article
- CMOS-EMBEDDED MICROFLUIDICS FOR CHANNEL-ADDRESSABLE PARALLEL READOUT OF SPAD FLUORESCENCE LIFETIME SENSORS.Proceedings. IEEE International Conference on Micro Electro Mechanical Systems · 2026Article
- Optical Detection Techniques for Biomedical Sensing: A Review of Printed Circuit Board (PCB)-Based Lab-on-Chip Systems.Micromachines · 2025Review
- Area-Efficient Mixed-Signal Time-to-Digital Converter Integration for Time-Resolved Photon Counting.Sensors (Basel, Switzerland) · 2024Article
- A compact microfluidic laser-induced fluorescence immunoassay system using avalanche photodiode for rapid detection of alpha-fetoprotein.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Fluorescence Multi-Detection Device Using a Lensless Matrix Addressable microLED Array.Biosensors · 2024Article
- A Novel Strategy for Rapid Fluorescence Detection of FluB and SARS-CoV-2.Molecules (Basel, Switzerland) · 2023Article
- Recent advances and application of whole genome amplification in molecular diagnosis and medicine.MedComm · 2022Review
- Real-time multispectral fluorescence lifetime imaging using Single Photon Avalanche Diode arrays.Scientific reports · 2020Article
- Recent Advances on Thermal Management of Flexible Inorganic Electronics.Micromachines · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We describe the integration of techniques and technologies to develop a Point-of-Care for molecular diagnosis PoC-MD, based on a fluorescence lifetime measurement. Our PoC-MD is a low-cost, simple, fast, and easy-to-use general-purpose platform, aimed at carrying out fast diagnostics test through label detection of a variety of biomarkers. It is based on a 1-D array of 10 ultra-sensitive Single-Photon Avalanche Diode (SPAD) detectors made in a 0.18 μm High-Voltage Complementary Metal Oxide Semiconductor (HV-CMOS) technology. A custom microfluidic polydimethylsiloxane cartridge to insert the sample is straightforwardly positioned on top of the SPAD array without any alignment procedure with the SPAD array. Moreover, the proximity between the sample and the gate-operated SPAD sensor makes unnecessary any lens or optical filters to detect the fluorescence for long lifetime fluorescent dyes, such as quantum dots. Additionally, the use of a low-cost laser diode as pulsed excitation source and a Field-Programmable Gate Array (FPGA) to implement the control and processing electronics, makes the device flexible and easy to adapt to the target label molecule by only changing the laser diode. Using this device, reliable and sensitive real-time proof-of-concept fluorescence lifetime measurement of quantum dot Qdot
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.