Evidence map›Paper›PMID 30678199›Full record

Trial reportNutrients2019

Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults.

Adriana J van Ballegooijen, Joline W J Beulens, Leon J Schurgers, Elisa J de Koning, Paul Lips, Natasja M van Schoor, Marc G Vervloet

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Evolving our understanding of vitamin D, periostin levels and cardiovascular risk in the elderly: a cross sectional study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  2. Article
  3. The Role of Vitamin K in CKD-MBD.Current osteoporosis reports · 2022
    Review
  4. Review
  5. Article
  6. Review
  7. ERJ open research · 2020
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Adriana J van BallegooijenDepartment of Nephrology, and Amsterdam Cardiovascular Science, VU University Medical Center, 1081 HV Amsterdam, The Netherlands. aj.vanballegooijen@vumc.nl.
Joline W J BeulensDepartment of Epidemiology & Biostatistics, and the Amsterdam Public Health Institute, VU University Medical Center, 1081 HV Amsterdam, The Netherlands. j.beulens@vumc.nl.
Leon J SchurgersDepartment of Biochemistry, Maastricht University, 6211 LK Maastricht, The Netherlands. l.schurgers@maastrichtuniversity.nl.ORCID 0000-0001-7867-6957
Elisa J de KoningDepartment of Epidemiology & Biostatistics, and the Amsterdam Public Health Institute, VU University Medical Center, 1081 HV Amsterdam, The Netherlands. ej.dekoning@vumc.nl.
Paul LipsDepartment of Internal Medicine, and Amsterdam Public Health Research Institute, VU University Medical Center, 1007 MB Amsterdam, The Netherlands. p.lips@vumc.nl.
Natasja M van SchoorDepartment of Epidemiology & Biostatistics, and the Amsterdam Public Health Institute, VU University Medical Center, 1081 HV Amsterdam, The Netherlands. nm.vanschoor@vumc.nl.
Marc G VervloetDepartment of Nephrology, and Amsterdam Cardiovascular Science, VU University Medical Center, 1081 HV Amsterdam, The Netherlands. m.vervloet@vumc.nl.ORCID 0000-0003-4607-9415
Amsterdam UMC Location Vrije Universiteit Amsterdam · NLMaastricht University · NLUniversity Medical Center Utrecht · NL

Funding

Nierstichting 16OKG02
6 · The paper itself

Abstract

Vitamin D supplementation has been widely promoted to restore 25-hydroxyvitamin D concentrations; however, experimental evidence suggests a nutrient interaction with vitamin K. We assessed the effects of 1200 IU vitamin D₃ per day versus placebo for six months on vitamin K status in a randomized, double-blind, placebo-controlled trial with participants aged 60⁻80 years with depressive symptoms and ≥1 functional limitation for a secondary analysis. Stored baseline and six-month follow-up blood samples were available for 131 participants (

Indexed as

AgedCalcium-Binding ProteinsCholecalciferolDouble-Blind MethodExtracellular Matrix ProteinsFemaleGene Expression RegulationHumansMaleMatrix Gla ProteinMiddle AgedCalcium-Binding ProteinsCholecalciferolExtracellular Matrix ProteinsMatrix Gla Proteinrandomized controlled trialvitamin D supplementationvitamin K status

Identifiers

PMID30678199
PMCPMC6413026
OpenAlexW2913587126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.