ArticleNutrients2019
Evidence that Nitric Oxide is Involved in the Blood Pressure Lowering Effect of the Peptide AVFQHNCQE in Spontaneously Hypertensive Rats.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Protein hydrolysates derived from poultry by-products as nutraceuticals: Bioactive potential, limitations, safety considerations, and commercialization perspectives.Poultry science · 2026Review
- Potential antihypertensive activity of novel peptides from green basil leaves.BMC complementary medicine and therapies · 2023Article
- Valorization of Chicken Slaughterhouse Byproducts to Obtain Antihypertensive Peptides.Nutrients · 2023Review
- Role of Chrononutrition in the Antihypertensive Effects of Natural Bioactive Compounds.Nutrients · 2022Review
- Bioactivity of peptides obtained from poultry by-products: A review.Food chemistry: X · 2022Article
- Compensatory role of endogenous sulfur dioxide in nitric oxide deficiency-induced hypertension.Redox biology · 2021Article
- Molecular mechanism ofChinese herbal medicines · 2021Article
- Implication of Opioid Receptors in the Antihypertensive Effect of a Novel Chicken Foot-Derived Peptide.Biomolecules · 2020Article
- Dietary Bioactive Compounds and Human Health and Disease.Nutrients · 2020Article
- Relationship between Nutrition and Alcohol Consumption with Blood Pressure: The ESTEBAN Survey.Nutrients · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
AVFQHNCQE is an antihypertensive nonapeptide obtained from a chicken foot protein hydrolysate. The present study aims to investigate the mechanisms involved in its blood pressure (BP)-lowering effect. Male (17⁻20 weeks old) spontaneously hypertensive rats (SHR) were used in this study. Rats were divided into two groups and orally administered water or 10 mg/kg body weight (bw) AVFQHNCQE. One hour post-administration, animals of both groups were intra-peritoneally treated with 1 mL of saline or with 1 mL of saline containing 30 mg/kg bw Nω-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, or with 1 mL of saline containing 5 mg/kg bw indomethacin, which is an inhibitor of prostacyclin synthesis (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.