Evidence map›Paper›PMID 30678177›Full record

ArticleMolecules (Basel, Switzerland)2019

Comparison between Exhaustive and Equilibrium Extraction Using Different SPE Sorbents and Sol-Gel Carbowax 20M Coated FPSE Media.

Angela Tartaglia, Marcello Locatelli, Abuzar Kabir, Kenneth G Furton, Daniela Macerola, Elena Sperandio, Silvia Piccolantonio, Halil I Ulusoy, Fabio Maroni, Pantaleone Bruni and 2 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Angela TartagliaDepartment of Pharmacy, University of Chieti⁻Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy. angela.tartaglia@unich.it.
Marcello LocatelliDepartment of Pharmacy, University of Chieti⁻Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy. m.locatelli@unich.it.
Abuzar KabirDepartment of Chemistry and Biochemistry, International Forensic Research Institute, Florida International University, 11200 SW 8th St, Miami, FL 33199, USA. akabir@fiu.edu.ORCID 0000-0002-3740-8857
Kenneth G FurtonDepartment of Chemistry and Biochemistry, International Forensic Research Institute, Florida International University, 11200 SW 8th St, Miami, FL 33199, USA. furtonk@fiu.edu.
Daniela MacerolaDepartment of Pharmacy, University of Chieti⁻Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy. daniela.macer@gmail.com.
Elena SperandioDepartment of Pharmacy, University of Chieti⁻Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy. sperandioelena94@gmail.com.
Silvia PiccolantonioDepartment of Pharmacy, University of Chieti⁻Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy. silvia.piccolantonio@studenti.unich.it.
Halil I UlusoyDepartment of Analytical Chemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas 58140, Turkey. hiulusoy@yahoo.com.ORCID 0000-0002-8742-5145
Fabio MaroniDepartment of Pharmacy, University of Chieti⁻Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy. fabio.maroni@unich.it.ORCID 0000-0002-2534-5668
Pantaleone BruniDepartment of Pharmacy, University of Chieti⁻Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy. pantaleonebruni@libero.it.ORCID 0000-0003-3728-0133
Fausto CroceDepartment of Pharmacy, University of Chieti⁻Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy. fausto.croce@unich.it.ORCID 0000-0001-9562-2694
Victoria F SamanidouLaboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. samanidu@chem.auth.gr.ORCID 0000-0002-8493-1106

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper reports the performance comparison between the exhaustive and equilibrium extraction using classical Avantor C18 solid phase extraction (SPE) sorbent, hydrophilic-lipophilic balance (HLB) SPE sorbent, Sep-Pak C18 SPE sorbent, novel sol-gel Carbowax 20M (sol-gel CW 20M) SPE sorbent, and sol-gel CW 20M coated fabric phase sorptive extraction (FPSE) media for the simultaneous extraction and analysis of three inflammatory bowel disease (IBD) drugs that possess logP values (polarity) ranging from 1.66 for cortisone, 2.30 for ciprofloxacin, and 2.92 for sulfasalazine. Both the commercial SPE phases and in-house synthesized sol-gel CW 20M SPE phases were loaded in SPE cartridges and the extractions were carried out under an exhaustive extraction mode. FPSE was carried out under an equilibrium extraction mode. The drug compounds were resolved using a Luna C18 column (250 mm × 4.6 mm; 5 m particle size) in gradient elution mode within 20 min and the method was validated in compliance with international guidelines for the bioanalytical method validation. Novel in-house synthesized and loaded sol-gel CW 20M SPE sorbent cartridges were characterized in terms of their extraction capability, breakthrough volume, retention volume, hold-up volume, number of the theoretical plate, and the retention factor.

Indexed as

Solid Phase ExtractionSolid Phase MicroextractionAdsorptionAnti-Inflammatory AgentsChemical PhenomenaCoated Materials, BiocompatibleGelsHydrophobic and Hydrophilic InteractionsModels, ChemicalMolecular StructurePolyethylene GlycolsSpectroscopy, Fourier Transform InfraredThermogravimetryAnti-Inflammatory AgentsCoated Materials, BiocompatibleGelsPolyethylene GlycolsextractionFPSEHPLC-PDAIBDin-house loaded SPEmethod validation

Identifiers

PMID30678177
PMCPMC6385024

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.