Evidence map›Paper›PMID 30678164›Full record

ReviewInternational journal of molecular sciences2019

Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines.

Leila Kheirandish-Gozal, David Gozal

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07723144 (Identification of Biomarkers to Understand the Pathogenesis of Obstructive Sleep Apnea.), which is not on this map. Cited by 180 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 10 pooled it
19.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07723144 narecruitingnot on this mapstarted 2025, after this paper: background citation

Identification of Biomarkers to Understand the Pathogenesis of Obstructive Sleep Apnea.

TypeinterventionalSponsorMedical University of BialystokRan2025 to 2029Enrolled120ConditionsObstructive Sleep Apnea, Obstructive Sleep Apnea (OSA), Obstructive Sleep Apnea (OSAS), Obstructive Sleep Apnea (SAOS)ArmsPositive Airway Pressure (PAP) Therapy
3 · Its place in the literature

Who cites it

180 citing papers in PubMed, 10 syntheses or guidelines pooled it, 323 citations in OpenAlex.

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  11. Nasal biomarker inflammatory profile in response to intranasal corticosteroids in pediatric obstructive sleep apnea syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
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120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Leila Kheirandish-GozalChild Health Research Institute, Department of Child Health, University of Missouri School of Medicine, Columbia, MO 65201, USA. gozall@health.missouri.edu.
David GozalChild Health Research Institute, Department of Child Health, University of Missouri School of Medicine, Columbia, MO 65201, USA. gozald@health.missouri.edu.ORCID 0000-0001-8195-6036
University of Missouri Health System · US

Funding

National Institutes of Health HL130984
6 · The paper itself

Abstract

Obstructive sleep apnea syndrome (OSAS) is a markedly prevalent condition across the lifespan, particularly in overweight and obese individuals, which has been associated with an independent risk for neurocognitive, behavioral, and mood problems as well as cardiovascular and metabolic morbidities, ultimately fostering increases in overall mortality rates. In adult patients, excessive daytime sleepiness (EDS) is the most frequent symptom leading to clinical referral for evaluation and treatment, but classic EDS features are less likely to be reported in children, particularly among those with normal body-mass index. The cumulative evidence collected over the last two decades supports a conceptual framework, whereby sleep-disordered breathing in general and more particularly OSAS should be viewed as low-grade chronic inflammatory diseases. Accordingly, it is assumed that a proportion of the morbid phenotypic signature in OSAS is causally explained by underlying inflammatory processes inducing end-organ dysfunction. Here, the published links between OSAS and systemic inflammation will be critically reviewed, with special focus on the pro-inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), since these constitute classical prototypes of the large spectrum of inflammatory molecules that have been explored in OSAS patients.

Indexed as

AnimalsCytokinesHumansInflammationInterleukin-6Sleep Apnea, ObstructiveTumor Necrosis Factor-alphaCytokinesInterleukin-6Tumor Necrosis Factor-alphacytokinesexcessive daytime sleepinessinflammationsleepsleep apnea

Identifiers

PMID30678164
PMCPMC6387387
OpenAlexW2914961860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.