ArticleGels (Basel, Switzerland)2019
Physical Interactions Strengthen Chemical Gelatin Methacryloyl Gels.
Article in Gels (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- 3D bioprinted bilayer GelMA/HAp hydrogel scaffold functionalized with miR-140-5p-modified MSCs for enhanced osteochondral regeneration.Journal of orthopaedic surgery and research · 2026Article
- Designing Tunable GelMA Hydrogels by Integrating Mammalian and Non-Mammalian Gelatins.Gels (Basel, Switzerland) · 2026Article
- Functional Group Chemistry Modulates Cellular Responses to Soluble Gelatin Derivatives Independent of Crosslinking.Biomolecules · 2026Article
- Impact of Composition and Autoclave Sterilization on the Mechanical and Biological Properties of ECM-Mimicking Cryogels.Polymers · 2024Article
- Powdered Cross-Linked Gelatin Methacryloyl as an Injectable Hydrogel for Adipose Tissue Engineering.Gels (Basel, Switzerland) · 2024Article
- Understanding the Molecular Conformation and Viscoelasticity of Low Sol-Gel Transition Temperature Gelatin Methacryloyl Suspensions.International journal of molecular sciences · 2023Article
- Sequential Cross-linking of Gallic Acid-Functionalized GelMA-Based Bioinks with Enhanced Printability for Extrusion-Based 3D Bioprinting.Biomacromolecules · 2023Article
- Photo-Crosslinkable Hydrogels for 3D Bioprinting in the Repair of Osteochondral Defects: A Review of Present Applications and Future Perspectives.Micromachines · 2022Review
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- Differentiation of physical and chemical cross-linking in gelatin methacryloyl hydrogels.Scientific reports · 2021Article
- Precise control of synthetic hydrogel network structure via linear, independent synthesis-swelling relationships.Science advances · 2021Article
- Injectable Cucurbit[8]uril-Based Supramolecular Gelatin Hydrogels for Cell Encapsulation.ACS macro letters · 2020Article
- Advanced gelatin-based vascularization bioinks for extrusion-based bioprinting of vascularized bone equivalents.Scientific reports · 2020Article
- Advanced formulation of methacryl- and acetyl-modified biomolecules to achieve independent control of swelling and stiffness in printable hydrogels.Journal of materials science. Materials in medicine · 2019Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemically cross-linkable gelatin methacryloyl (GM) derivatives are getting increasing attention regarding biomedical applications. Thus, thorough investigations are needed to achieve full understanding and control of the physico-chemical behavior of these promising biomaterials. We previously introduced gelatin methacryloyl acetyl (GMA) derivatives, which can be used to control physical network formation (solution viscosity, sol-gel transition) independently from chemical cross-linking by variation of the methacryloyl-to-acetyl ratio. It is known that temperature dependent physical network formation significantly influences the mechanical properties of chemically cross-linked GM hydrogels. We investigated the temperature sensitivity of GM derivatives with different degrees of modification (GM2, GM10), or similar degrees of modification but different methacryloyl contents (GM10, GM2A8). Rheological analysis showed that the low modified GM2 forms strong physical gels upon cooling while GM10 and GM2A8 form soft or no gels. Yet, compression testing revealed that all photo cross-linked GM(A) hydrogels were stronger if cooling was applied during hydrogel preparation. We suggest that the hydrophobic methacryloyl and acetyl residues disturb triple helix formation with increasing degree of modification, but additionally form hydrophobic structures, which facilitate chemical cross-linking.
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