Evidence map›Paper›PMID 30678135›Full record

ArticleMolecules (Basel, Switzerland)2019

Inhibitory Effects of Roseoside and Icariside E4 Isolated from a Natural Product Mixture (No-ap) on the Expression of Angiotensin II Receptor 1 and Oxidative Stress in Angiotensin II-Stimulated H9C2 Cells.

Eun Young Hong, Tae Yang Kim, Gwan Ui Hong, Hanna Kang, Jung-Yun Lee, Jae Yeo Park, Se-Chan Kim, Young Ho Kim, Myung-Hee Chung, Young-In Kwon and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Phytochemical Profiling of Processed Açaí Pulp (Antioxidants (Basel, Switzerland) · 2025
    Article
  4. GSTP1 inhibits angiotensin II-induced atrial fibrillation by regulating ferroptosis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  5. Roseoside Is a Bioactive Compound inMolecules (Basel, Switzerland) · 2024
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Frontiers in pharmacology · 2021
    Article
  12. Evidence-based complementary and alternative medicine : eCAM · 2021
    Article
  13. Article
  14. Article
  15. Phytochemical and Therapeutic Potential ofJournal of evidence-based integrative medicine
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Eun Young HongLife & Science Research Center, Hyunsung Vital Co. Ltd., Seoul 07255, Korea. h_medical@naver.com.
Tae Yang KimDepartment of Food and Nutrition, Hannam University, Daejeon 34054, Korea. xodid5606@naver.com.
Gwan Ui HongLife & Science Research Center, Hyunsung Vital Co. Ltd., Seoul 07255, Korea. gwanuihong@gmail.com.
Hanna KangDepartment of Food and Nutrition, Hannam University, Daejeon 34054, Korea. hanna9506@hanmail.net.
Jung-Yun LeeNatural Products Institute, Proteinworks Co. Ltd., Daejeon 07255, Korea. seembeeks@hanmail.net.
Jae Yeo ParkLife & Science Research Center, Hyunsung Vital Co. Ltd., Seoul 07255, Korea. legolas018@naver.com.
Se-Chan KimDepartment of Bio Quality Control, Korea Bio Polytechnic, Chungnam 32943, Korea. sechage@kopo.ac.kr.
Young Ho KimDepartment of Pharmacy, Choongnam National University, Daejeon 34134, Korea. yhk@cnu.ac.kr.
Myung-Hee ChungGil Hospital and Lee Gil Ya Cancer & Diabetes Institute, Gachon University, Inchon 21999, Korea. mhchung@gachon.ac.kr.
Young-In KwonDepartment of Food and Nutrition, Hannam University, Daejeon 34054, Korea. youngk@hnu.kr.ORCID 0000-0002-8069-8212
Jai Youl RoLife & Science Research Center, Hyunsung Vital Co. Ltd., Seoul 07255, Korea. jyro426@skku.edu.
Hannam University · KRChungnam National University · KRDeleted InstitutionKorea Bio Polytechnic College · KRSungkyunkwan University · KR

Funding

Life & Science Research Center of Hyunsung Vital 2018002
6 · The paper itself

Abstract

Hypertension is a major risk factor for the development of cardiovascular diseases. This study aimed to elucidate whether the natural product mixture No-ap (NA) containing

Indexed as

Angiotensin IIAnimalsBiological ProductsChemokine CCL2Gene Expression RegulationGlucosidesGlycosidesHumansHydrogen PeroxideLignansNorisoprenoidsOxidation-ReductionOxidative StressRatsReceptor, Angiotensin, Type 1RNA, MessengerAgtr1a protein, ratAngiotensin IIBiological ProductsCcl2 protein, ratChemokine CCL2GlucosidesGlycosidesHydrogen Peroxideicariside E4LignansNorisoprenoidsReceptor, Angiotensin, Type 1RNA, MessengerroseosideTransforming Growth Factor beta1Tumor Necrosis Factor-alphaangiotensin IIcardiomyocytes (H9C2 cells)hypertensionicariside E4No-ap (natural product mixture)reactive oxygen speciesroseoside

Identifiers

PMID30678135
PMCPMC6384670
OpenAlexW2913333413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.