Evidence map›Paper›PMID 30678127›Full record

ArticleCancers2019

The Activity of Kv 11.1 Potassium Channel Modulates F-Actin Organization During Cell Migration of Pancreatic Ductal Adenocarcinoma Cells.

Sagar Manoli, Stefano Coppola, Claudia Duranti, Matteo Lulli, Lara Magni, Nirmala Kuppalu, Nikolaj Nielsen, Thomas Schmidt, Albrecht Schwab, Andrea Becchetti and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Ion channels and actin: A tale of two friends.Histology and histopathology · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Ion Channel Involvement in Tumor Drug Resistance.Journal of personalized medicine · 2022
    Review
  10. Article
  11. Article
  12. Influence of Kv11.1 (hERG1) KPflugers Archiv : European journal of physiology · 2021
    Article
  13. Review
  14. IdentifyingPeerJ · 2020
    Article
  15. Review
  16. KFrontiers in pharmacology · 2020
    Article
  17. hERG KFrontiers in pharmacology · 2020
    Article
  18. Review
  19. Role of ion channels in gastrointestinal cancer.World journal of gastroenterology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Sagar ManoliDepartment of Experimental and Clinical Medicine, University of Florence, Viale GB Morgagni 50, 50134 Florence, Italy. aschwab@uni-muenster.de.
Stefano CoppolaDepartment of Experimental and Clinical Medicine, University of Florence, Viale GB Morgagni 50, 50134 Florence, Italy. stefano.coppola87@gmail.com.
Claudia DurantiDepartment of Experimental and Clinical Medicine, University of Florence, Viale GB Morgagni 50, 50134 Florence, Italy. claudia.duranti@unifi.it.
Matteo LulliDepartment of Experimental Biochemical and Clinical Sciences, University of Firenze, Viale GB Morgagni 50, 50134 Firenze, Italy. matteo.lulli@unifi.it.ORCID 0000-0002-8528-4094
Lara MagniDepartment of Experimental and Clinical Medicine, University of Florence, Viale GB Morgagni 50, 50134 Florence, Italy. lara.magni@stud.unifi.it.
Nirmala KuppaluDepartment of Experimental and Clinical Medicine, University of Florence, Viale GB Morgagni 50, 50134 Florence, Italy. kurani17@gmail.com.
Nikolaj NielsenInstitut für Physiologie II, Robert-Koch-Str. 27b, D-48149 Münster, Germany. nikolaj_nielsen@hotmail.com.
Thomas SchmidtPhysics of Life Processes, Huygens-Kamerlingh Onnes Laboratory, Leiden University, Niels Bohrweg 2, 2333 CA Leiden, The Netherlands. Schmidt@Physics.LeidenUniv.nl.
Albrecht SchwabInstitut für Physiologie II, Robert-Koch-Str. 27b, D-48149 Münster, Germany. aschwab@uni-muenster.de.
Andrea BecchettiDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy. andrea.becchetti@unimib.it.ORCID 0000-0002-9297-0527
Annarosa ArcangeliDepartment of Experimental and Clinical Medicine, University of Florence, Viale GB Morgagni 50, 50134 Florence, Italy. annarosa.arcangeli@unifi.it.
University of Florence · ITLeiden University · NLUniversity of Milano-Bicocca · IT

Funding

Associazione Italiana per la Ricerca sul Cancro IG15627FP7 People: Marie-Curie Actions 289648
6 · The paper itself

Abstract

Cell migration exerts a pivotal role in tumor progression, underlying cell invasion and metastatic spread. The cell migratory program requires f-actin re-organization, generally coordinated with the assembly of focal adhesions. Ion channels are emerging actors in regulating cell migration, through different mechanisms. We studied the role of the voltage dependent potassium channel K

Indexed as

desmoplastic matrixfibronectinfilopodiafocal adhesionshERG1hypoxiaintegrinsintracellular Ca2+ concentrationpancreatic cancerstress fibers

Identifiers

PMID30678127
PMCPMC6406627
OpenAlexW2912777554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.