ArticleBrain sciences2019
Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (
Article in Brain sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Enhancing biocompatibility of the brain-machine interface: A review.Bioactive materials · 2024Review
- Insertional effect following electrode implantation: an underreported but important phenomenon.Brain communications · 2024Review
- Light microscopic and heterogeneity analysis of astrocytes in the common marmoset brain.Journal of neuroscience research · 2021Article
- Intracortical Microelectrode Array Unit Yield under Chronic Conditions: A Comparative Evaluation.Micromachines · 2021Review
- More Than Cell Markers: Understanding Heterogeneous Glial Responses to Implantable Neural Devices.Frontiers in cellular neuroscience · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microelectrode implants are an important tool in neuroscience research and in developing brain⁻machine interfaces. Data from rodents have consistently shown that astrocytes are recruited to the area surrounding implants, forming a glial scar that increases electrode impedance and reduces chronic utility. However, studies in non-human primates are scarce, with none to date in marmosets. We used glial fibrillary acidic protein (GFAP) immunostaining to characterize the acute and chronic response of the marmoset brain to microelectrodes. By using densitometry, we showed that marmoset astrocytes surround brain implants and that a glial scar is formed over time, with significant increase in the chronic condition relative to the acute condition animal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.