ArticleNeuroepidemiology2019
Vascular Risk Factors and Findings on Brain MRI of Elderly Adult American Indians: The Strong Heart Study.
Article in Neuroepidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Association between Type 2 Diabetes Mellitus and Brain Atrophy: A Meta-Analysis.Diabetes & metabolism journal · 2022Pooled it
- Risk factors and population attributable fraction for dementia in American Indians: The Strong Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Epidemiology of Head Injury and Associations with Clinical and Neuropsychological Test Scores in Older American Indians: Data from the Strong Heart Study.Journal of racial and ethnic health disparities · 2026Article
- Urinary selenium, cranial MRI, and cognitive function in American Indians: The Strong Heart Study.Environmental research · 2025Article
- Cognitive reserve is associated with education, social determinants, and cognitive outcomes among older American Indians in the Strong Heart Study.Communications psychology · 2025Article
- Sex differences in the association of cardiometabolic risk scores and blood pressure measurements with white matter hyperintensities in diverse older adults-HABS-HD.Frontiers in aging neuroscience · 2025Article
- Carotid artery atherosclerosis, MRI-defined structural brain abnormalities, and cognitive performance in elderly American Indians: The Strong Heart Study.Frontiers in epidemiology · 2025Article
- Epidemiology and prevalence of dementia and Alzheimer's disease in American Indians: Data from the Strong Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Psychological and social support associations with mortality and cardiovascular disease in middle-aged American Indians: the Strong Heart Study.Social psychiatry and psychiatric epidemiology · 2022Article
- Effects of Obesity, Blood Pressure, and Blood Metabolic Biomarkers on Grey Matter Brain Healthcare Quotient: A Large Cohort Study of a Magnetic Resonance Imaging Brain Screening System in Japan.Journal of clinical medicine · 2022Article
- Risk Factors in Adolescence for the Development of Elevated Blood Pressure and Hypertension in American Indian and Alaskan Native Adults.Journal of immigrant and minority health · 2021Article
- The interaction on hypertension between family history and diabetes and other risk factors.Scientific reports · 2021Article
- Lifestyle Risk Factors and Findings on Brain Magnetic Resonance Imaging of Older Adult American Indians: The Strong Heart Study.Neuroepidemiology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundClinical stroke is prevalent in American Indians, but the risk factors for cerebrovascular pathology have not been well-studied in this population. The purpose of this study was to correlate abnormalities on brain magnetic resonance imaging (MRI) with clinical risk factors in a cohort of elderly American Indians.
methodsBrain MRI scans from 789 participants of the Strong Heart Study were analyzed for infarcts, hemorrhage, white matter disease, and measures of cerebral atrophy including ventricular and sulcal grade and total brain volume. Clinical risk factors included measures of hypertension, diabetes, and high levels of low-density lipoprotein (LDL) cholesterol. Regression models adjusted for potential confounders were used to estimate associations between risk factors and brain MRI outcomes.
results-Hypertension was associated with the presence of infarcts (p = 0.001), ventricle enlargement (p = 0.01), and increased white matter hyperintensity volume (p = 0.01). Diabetes was associated with increased prevalence of cerebral atrophy (p < 0.001), ventricular enlargement (p = 0.001), and sulcal widening (p = 0.001). High LDL was not significantly associated with any of the measured cranial imaging outcomes.
conclusionsThis study found risk factors for cerebrovascular disease in American Indians similar to those seen in other populations and provides additional evidence for the important roles of hypertension and diabetes in promoting cerebral infarcts and brain atrophy, respectively.
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