ReviewAging2019
Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan.
Review in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Reproductive lifespan and hormonal therapy in relation to later-life neurovascular health: A population-based study of women in the Gothenburg H70-1944 Birth Cohort.medRxiv : the preprint server for health sciences · 2026Article
- Neurodevelopmental origins of age-related neurodegenerative diseases.EBioMedicine · 2026Review
- ApoE expression across the CNS: Who, What, Where, When, and How (much)?Molecular neurodegeneration advances · 2026Review
- Article
- Childhood Trauma andmedRxiv : the preprint server for health sciences · 2025Article
- Article
- A lifetime perspective on risk factors for cognitive decline with a special focus on early events.Cerebral circulation - cognition and behavior · 2024Article
- Article
- Association of APOE Serum Levels andGenes · 2022Article
- Effect of Apolipoprotein E ε4 Allele on the Progression of Carotid Atherosclerosis Through Apolipoprotein Levels.Pharmacogenomics and personalized medicine · 2022Article
- Dissociable effects ofNature aging · 2021Article
- Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults.Scientific reports · 2021Article
- Race, APOE genotypes, and cognitive decline among middle-aged urban adults.Alzheimer's research & therapy · 2021Article
- Apolipoprotein E and Atherosclerosis.Current atherosclerosis reports · 2021Review
- APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid.Journal of Alzheimer's disease : JAD · 2021Article
- Traumatic Brain Injury Exposure Lowers Age of Cognitive Decline in AD and Non-AD Conditions.Frontiers in neurology · 2021Article
- APOE in the normal brain.Neurobiology of disease · 2020Review
- Antihypertensive medications ameliorate Alzheimer's disease pathology by slowing its propagation.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- The Specific Impact of Apolipoprotein E Epsilon 2 on Cognition and Brain Function in Cognitively Normal Elders and Mild Cognitive Impairment Patients.Frontiers in aging neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The central nervous system (CNS) is the cellular substrate for the integration of complex, dynamic, constant, and simultaneous interactions among endogenous and exogenous stimuli across the entire human lifespan. Numerous studies on aging-related brain diseases show that some genes identified as risk factors for some of the most common neurodegenerative diseases - such as the allele 4 of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.