ArticleObesity (Silver Spring, Md.)2019
Heterogeneity in Response to Treatment of Adolescents with Severe Obesity: The Need for Precision Obesity Medicine.
Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Toward Participatory Precision Health With Co-Designed Recommendations: Systematic Review of Just-in-Time Adaptive Interventions in Adolescents and Young Adults.Journal of medical Internet research · 2026Pooled it
- Exercise training modalities for cardiorespiratory fitness and blood pressure in children and adolescents with obesity: a systematic review and network meta-analysis.Frontiers in public health · 2026Pooled it
- Body Composition Changes in Adolescents Who Underwent Bariatric Surgery: A Systematic Review and Meta-analysis.Current obesity reports · 2024Pooled it
- Predictors of BMI reduction with phentermine/topiramate in adolescents with obesity.International journal of obesity (2005) · 2025Trial
- Evaluating potential predictors of weight loss response to liraglutide in adolescents with obesity: A post hoc analysis of the randomized, placebo-controlled SCALE Teens trial.Pediatric obesity · 2023Trial
- Response heterogeneity to lifestyle intervention among Latino adolescents.Pediatric diabetes · 2020Trial
- Relevant Weight Reduction and Reversed Metabolic Co-morbidities Can Be Achieved by Duodenojejunal Bypass Liner in Adolescents with Morbid Obesity.Obesity surgery · 2020Trial
- Beyond the Scale: Setting Goals for Outcomes Beyond Weight in Evidence-based Obesity Treatment.Current obesity reports · 2026Review
- Obesity Phenotyping in Children and Adolescents: Next Steps Towards Precision Medicine in Pediatric Obesity.Nutrients · 2026Review
- Pharmacologic treatment of obesity in adults: Standards of care in overweight and obesity.BMJ open diabetes research & care · 2026Review
- Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality?Obesity (Silver Spring, Md.) · 2025Review
- Review
- Current and future state of pharmacological management of pediatric obesity.International journal of obesity (2005) · 2025Review
- Assessment and medical management of weight regain after adolescent metabolic and bariatric surgery: a narrative review.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025Review
- Anti-Obesity Medication in the Management of Children and Adolescents With Obesity: Recent Developments and Research Gaps.Clinical endocrinology · 2025Review
- Sculpting Success: The Importance of Diet and Physical Activity to Support Skeletal Muscle Health during Weight Loss with New Generation Anti-Obesity Medications.Current developments in nutrition · 2024Review
- Body Mass Index and Levonorgestrel Device Expulsion in Adolescents and Young Adults.Journal of pediatric and adolescent gynecology · 2024Article
- Greater Improvement in Obesity Among Children With Prediabetes in a Clinical Weight Management Program.Childhood obesity (Print) · 2024Article
- Exposure to 4,4'-DDE in visceral adipose tissue and weight loss in adolescents from the Teen-LABS cohort.Obesity (Silver Spring, Md.) · 2024Article
- SMART use of medications for the treatment of adolescent severe obesity: A sequential multiple assignment randomized trial protocol.Contemporary clinical trials · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTreating pediatric severe obesity is challenging because of the complex biological, behavioral, and environmental factors that underpin the disease. The multifactorial etiology of obesity combined with the physiologic complexity of the energy regulatory system contributes to treatment variability. The goal of this secondary analysis of pooled data was to describe the degree of individual variation in response to various interventions among adolescents with severe obesity.
methodsData from three centers across the United States conducting either lifestyle (n = 53), pharmacotherapy (n = 40), or metabolic and bariatric surgery (n = 78) interventions were pooled. Inclusion criteria were severe obesity at baseline and at least one follow-up visit > 30 days after treatment start.
resultsChange in BMI following intervention ranged from -50.2% to +12.9%, with each intervention (lifestyle [range: -25.4% to 5.0%], pharmacotherapy [range: -10.8% to 12.9%], and metabolic and bariatric surgery [range: -50.2% to -13.3%]) exhibiting wide individual variation in response. Changes in cardiometabolic risk factors demonstrated similarly high variability.
conclusionsAdolescents with severe obesity demonstrated a high degree of heterogeneity in terms of BMI reduction and cardiometabolic risk factor response across treatment modalities. Reporting individual response data in trials and identifying factors driving variability in response will be vital for advancing precision medicine approaches to address obesity.
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