Trial reportPloS one2019
High-pitch, 120 kVp/30 mAs, low-dose dual-source chest CT with iterative reconstruction: Prospective evaluation of radiation dose reduction and image quality compared with those of standard-pitch low-dose chest CT in healthy adult volunteers.
Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Thoracic-abdominopelvic contrast-enhanced dual-source computed tomography with a high-pitch acquisition protocol and free breathing for reducing motion artifacts and scan time in patients with cancer: a prospective study.Quantitative imaging in medicine and surgery · 2025Article
- Application effect of low-dose spiral CT on pulmonary nodules and its diagnostic value for benign and malignant nodules.American journal of translational research · 2023Article
- Feasibility study of three-dimensional printing knee model using the ultra-low-dose CT scan for preoperative planning and simulated surgery.Insights into imaging · 2022Article
- Comparison of clinical diagnostic value of spiral CT with different dose in patients with early-stage peripheral lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Article
- Latest CT technologies in lung cancer screening: protocols and radiation dose reduction.Translational lung cancer research · 2021Review
- Optimization of imaging parameters in chest CT for COVID-19 patients: an experimental phantom study.Quantitative imaging in medicine and surgery · 2021Article
- Proposal of a low-dose, long-pitch, dual-source chest CT protocol on third-generation dual-source CT using a tin filter for spectral shaping at 100 kVp for CoronaVirus Disease 2019 (COVID-19) patients: a feasibility study.La Radiologia medica · 2020Article
- Radiation dose and image quality of high-pitch emergency abdominal CT in obese patients using third-generation dual-source CT (DSCT).Scientific reports · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeObjective of this study was to evaluate the effectiveness of the iterative reconstruction of high-pitch dual-source chest CT (IR-HP-CT) scanned with low radiation exposure compared with low dose chest CT (LDCT). MATERIALS AND
methodsThis study was approved by the institutional review board. Thirty healthy adult volunteers (mean age 44 years) were enrolled in this study. All volunteers underwent both IR-HP-CT and LDCT. IR-HP-CT was scanned with 120 kVp tube voltage, 30 mAs tube current and pitch 3.2 and reconstructed with sinogram affirmed iterative reconstruction. LDCT was scanned with 120 kVp tube voltage, 40 mAs tube current and pitch 0.8 and reconstructed with B50 filtered back projection. Image noise, and signal to noise ratio (SNR) of the infraspinatus muscle, subcutaneous fat and lung parenchyma were calculated. Cardiac motion artifact, overall image quality and artifacts was rated by two blinded readers using 4-point scale. The dose-length product (DLP) (mGy∙cm) were obtained from each CT dosimetry table. Scan length was calculated from the DLP results. The DLP parameter was a metric of radiation output, not of patient dose. Size-specific dose estimation (SSDE, mGy) was calculated using the sum of the anteroposterior and lateral dimensions and effective radiation dose (ED, mSv) were calculated using CT dosimetry index.
resultsApproximately, mean 40% of SSDE (2.1 ± 0.2 mGy vs. 3.5 ± 0.3 mGy) and 34% of ED (1.0 ± 0.1 mSv vs. 1.5 ± 0.1 mSv) was reduced in IR-HP-CT compared to LDCT (P < 0.0001). Image noise was reduced in the IR-HP-CT (16.8 ± 2.8 vs. 19.8 ± 3.4, P = 0.0001). SNR of lung and aorta of IR-HP-CT showed better results compared with that of LDCT (22.2 ± 5.9 vs. 33.0 ± 7.8, 1.9 ± 0.4 vs 1.1 ± 0.3, P < 0.0001). The score of cardiac pulsation artifacts were significantly reduced on IR-HP-CT (3.8 ± 0.4, 95% confidence interval, 3.7‒4.0) compared with LDCT (1.6 ± 0.6, 95% confidence interval, 1.3‒1.8) (P < 0.0001). SNR of muscle and fat, beam hardening artifact and overall subjective image quality of the mediastinum, lung and chest wall were comparable on both scans (P ≥ 0.05).
conclusionIR-HP-CT with 120 kVp and 30 mAs tube setting in addition to an iterative reconstruction reduced cardiac motion artifact and radiation exposure while representing similar image quality compared with LDCT.
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