ArticlePLoS genetics2019
Dissecting the pathways coordinating patterning and growth by plant boundary domains.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Unlocking grass leaf development: foundations for tunable cereal design.The New phytologist · 2025Review
- Homeodomain transcription factor regulation of leaf serrations in Arabidopsis thaliana.Journal of experimental botany · 2025Article
- Developmental rewiring of the NGAL/CUC/KLU network associated with pleiotropic roles of NGAL genes.The Plant journal : for cell and molecular biology · 2025Article
- WOX out, those teeth are sharp!Journal of experimental botany · 2025Article
- WOX1 controls leaf serration development via temporally restricting BRASSINAZOLE RESISTANT 1 and CUP SHAPED COTYLEDON 3 expression in Arabidopsis.Journal of experimental botany · 2025Article
- Cytochromes P450 evolution in the plant terrestrialization context.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- GhSBI1, a CUP-SHAPED COTYLEDON 2 homologue, modulates branch internode elongation in cotton.Plant biotechnology journal · 2024Article
- MIR164B ensures robust Arabidopsis leaf development by compensating for compromised POLYCOMB REPRESSIVE COMPLEX2 function.The Plant cell · 2024Article
- Model-based reconstruction of whole organ growth dynamics reveals invariant patterns in leaf morphogenesis.Quantitative plant biology · 2023Article
- De novo stem cell establishment in meristems requires repression of organ boundary cell fate.The Plant cell · 2022Article
- Boundary domain genes were recruited to suppress bract growth and promote branching in maize.Science advances · 2022Article
- An in situ sequencing approach maps PLASTOCHRON1 at the boundary between indeterminate and determinate cells.Plant physiology · 2022Article
- CRISPR/Cas9 mutants of tomato MICRORNA164 genes uncover their functional specialization in development.Plant physiology · 2021Article
- LATE MERISTEM IDENTITY1 regulates leaf margin development via the auxin transporter gene SMOOTH LEAF MARGIN1.Plant physiology · 2021Article
- NGATHA-LIKEs Control Leaf Margin Development by RepressingPlant physiology · 2020Article
- Molecular and Hormonal Regulation of Leaf Morphogenesis in Arabidopsis.International journal of molecular sciences · 2020Review
- Ectopic expression of the transcription factor CUC2 restricts growth by cell cycle inhibition inPlant signaling & behavior · 2020Article
- Transcription Factor Networks in Leaves ofPlants (Basel, Switzerland) · 2019Article
- IBR5 Regulates Leaf Serrations Development via Modulation of the Expression ofInternational journal of molecular sciences · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Boundary domains play important roles during morphogenesis in plants and animals, but how they contribute to patterning and growth coordination in plants is not understood. The CUC genes determine the boundary domains in the aerial part of the plants and, in particular, they have a conserved role in regulating leaf complexity across Angiosperms. Here, we used tooth formation at the Arabidopsis leaf margin controlled by the CUC2 transcription factor to untangle intertwined events during boundary-controlled morphogenesis in plants. Combining conditional restoration of CUC2 function with morphometrics as well as quantification of gene expression and hormone signaling, we first established that tooth morphogenesis involves a patterning phase and a growth phase. These phases can be separated, as patterning requires CUC2 while growth can occur independently of CUC2. Next, we show that CUC2 acts as a trigger to promote growth through the activation of three functional relays. In particular, we show that KLUH acts downstream of CUC2 to modulate auxin response and that expressing KLUH can compensate for deficient CUC2 expression during tooth growth. Together, we reveal a genetic and molecular network that allows coordination of patterning and growth by CUC2-defined boundaries during morphogenesis at the leaf margin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.