ReviewJournal of applied physiology (Bethesda, Md. : 1985)2019
Effect of heat stress on vascular outcomes in humans.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04588103 (The Effects of 8 Weeks of Lower Limb Heat Therapy, Moderate-intensity Cycling Exercise, or Both on Vascular Function in Young, Healthy Males and Females), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of 8 Weeks of Lower Limb Heat Therapy, Moderate-intensity Cycling Exercise, or Both on Vascular Function in Young, Healthy Males and Females
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effects of hot-water immersion on cardiovascular and cardiorespiratory health of healthy adults: A systematic review and meta-analysis.Physiological reports · 2026Pooled it
- Cutaneous Microvascular Functional Reserve is Associated with Kidney Function and Histopathologic Injury in CKD: The MAP-CKD Study.medRxiv : the preprint server for health sciences · 2026Article
- Acute hot-water immersion augments the diastolic blood pressure nocturnal dip in healthy adults.Experimental physiology · 2026Article
- The effect of repeated hot water immersion on microvascular function, glycaemic control and inflammation in White European and South Asian males.Experimental physiology · 2026Article
- Heat Therapy: Targeting Health, Disease, and Disability.Comprehensive Physiology · 2026Review
- Differential sensitivity of impedance plethysmography and photoplethysmography sensors to temperature-induced peripheral vasoconstriction.Scientific reports · 2026Article
- Article
- Eight weeks of post-exercise local heating does not improve cognition and plasma brain-derived neurotrophic factor concentrations.Experimental physiology · 2025Article
- Occupational Heat Exposure and Chronic Venous Disease: Barriers, Adaptations, and Implications for Sustainable Workplaces.Healthcare (Basel, Switzerland) · 2025Article
- Impact of heat exposure on sleep health and its population vulnerability in the United States.Environment international · 2025Article
- Heat thermotherapy to improve cardiovascular function and cardiometabolic health: A systematic review and meta-analysis.Experimental physiology · 2025Article
- Evaporative microclimate interval cooling reduces heat stress in thermal insulating protective clothing.Journal of occupational medicine and toxicology (London, England) · 2025Article
- Systemic cardiovascular and carotid baroreflex support of arterial pressure during recovery from passive heat stress in young and older adults.Physiological reports · 2025Article
- The acute effects of continuous and intermittent whole-body passive heating on cardiovascular disease risk indicators in healthy and young males and females.European journal of applied physiology · 2025Article
- Keratinocyte-specific angiotensin II receptor-associated protein deficiency exacerbates angiotensin II-dependent hypertension via activation of the skin renin-angiotensin system.Nature communications · 2025Article
- Home-based heat therapy lowers blood pressure and improves endothelial function in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Nitric oxide: Potential therapeutic target in Heat Stress-induced Multiple Organ Dysfunction.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- The pathogenesis and therapeutic strategies of heat stroke-induced endothelial injury.Frontiers in cell and developmental biology · 2025Review
- Hot Water Immersion as a Means to Prevent Cardiovascular Disease and Associated Mortality.Current cardiology reviews · 2025Review
- The effect of acute hot water immersion on cutaneous peripheral microvascular responses in males of White-European, Black-African and South-Asian descent.Temperature (Austin, Tex.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to its role as an environmental stressor, scientists have recently demonstrated the potential for heat to be a therapy for improving or mitigating declines in arterial health. Many studies at both ends of the scientific controls spectrum (tightly controlled, experimental vs. practical) have demonstrated the beneficial effects of heating on microvascular function (e.g., reactive hyperemia, cutaneous vascular conductance); endothelial function (e.g., flow-mediated dilation); and arterial stiffness (e.g., pulse-wave velocity, compliance, β-stiffness index). It is important to note that findings of beneficial effects are not unanimous, likely owing to the varied methodology in both heating protocols and assessments of outcome measures. Mechanisms of action for the effects of both acute and chronic heating are also understudied. Heat science is a very promising area of human physiology research, as it has the potential to contribute to approaches addressing the global cardiovascular disease burden, particularly in aging and at risk populations, and those for whom exercise is not feasible or recommended.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.