ArticleCNS neuroscience & therapeutics2019
BST1 rs4698412 allelic variant increases the risk of gait or balance deficits in patients with Parkinson's disease.
Article in CNS neuroscience & therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence From the COURAGE-PD Consortium.Neurology · 2022Pooled it
- Quality of life in Parkinson's disease: A systematic review and meta-analysis of comparative studies.CNS neuroscience & therapeutics · 2021Pooled it
- ModelingbioRxiv : the preprint server for biology · 2026Article
- The impact ofFrontiers in aging neuroscience · 2025Article
- Parkinson's disease and the risk of gastrointestinal cancers: a two-sample Mendelian randomization study.Journal of gastrointestinal oncology · 2024Article
- Genetic polymorphisms of bone marrow stromal cell antigen-1 (BST-1/CD157): implications for immune/inflammatory dysfunction in neuropsychiatric disorders.Frontiers in immunology · 2023Review
- A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism.Molecular brain · 2022Article
- Genetic correlation between thyroid hormones and Parkinson's disease.Clinical and experimental immunology · 2022Article
- Association analysis of SYT11, FGF20, GCH1 rare variants in Parkinson's disease.CNS neuroscience & therapeutics · 2022Article
- Identification of CD38 as a potential biomarker in skin cutaneous melanoma using bioinformatics analysis.Oncology letters · 2020Article
- Dysfunction in superior frontal gyrus associated with diphasic dyskinesia in Parkinson's disease.NPJ Parkinson's disease · 2020Article
- SNCA rs11931074 polymorphism correlates with spontaneous brain activity and motor symptoms in Chinese patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- BST1 rs4698412 allelic variant increases the risk of gait or balance deficits in patients with Parkinson's disease.CNS neuroscience & therapeutics · 2019Article
- Clinical or neuroimaging profiles in the assessment of genetic variants associated with neurodegenerative diseases.CNS neuroscience & therapeutics · 2019Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWe aimed to explore effects of bone marrow stromal cell antigen-1 (BST1) rs4698412 allelic variant on brain activation and associative clinical symptoms in Parkinson's disease (PD).
methodsA total of 49 PD patients and 47 healthy control (HC) subjects were recruited for clinical evaluations, blood samples collection for genotypes, and resting-state functional MRI (rs-fMRI) scans. Based on BST1 rs4698412 allelic variant (G → A), participants were further divided into 18 PD-GG, 31 PD-GA/AA, 20 HC-GG, and 27 HC-GA/AA carriers, which respectively indicated subjects carrying ancestral or risk allele in that locus in PD or HC. Two-way analysis of covariance (ANCOVA) was applied to investigate main effects and interactions between PD and BST1 rs4698412 allelic variant on brain function via amplitude of low-frequency fluctuations (ALFF). Spearman's correlations were then utilized to detect associations between interactive brain regions and clinical symptoms.
resultsCompared to HC subjects, PD patients exhibited increased ALFF values in left cerebellum_8 and cerebellum_9. Significant interaction was in right lingual gyrus, where there were the lowest ALFF values and ALFF values were only negatively associated with Timed Up and Go (TUG) test time in PD-GA/AA subgroup.
conclusionBST1 rs4698412-modulated lingual gyrus functional alterations could be related to gait and balance dysfunction in PD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.