Evidence map›Paper›PMID 30676318›Full record

ArticleeLife2019

Nephron progenitor commitment is a stochastic process influenced by cell migration.

Kynan T Lawlor, Luke Zappia, James Lefevre, Joo-Seop Park, Nicholas A Hamilton, Alicia Oshlack, Melissa H Little, Alexander N Combes

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 70 citations in OpenAlex.

  1. Review
  2. Lgr6Genes & diseases · 2026
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  19. Review
  20. Principles of human and mouse nephron development.Nature reviews. Nephrology · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Kynan T LawlorMurdoch Children's Research Institute, Parkville, Australia.ORCID 0000-0003-4080-5439
Luke ZappiaMurdoch Children's Research Institute, Parkville, Australia.ORCID 0000-0001-7744-8565
James LefevreDivision of Genomics of Development and Disease, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Joo-Seop ParkDivision of Pediatric Urology and Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.
Nicholas A HamiltonDivision of Genomics of Development and Disease, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.ORCID 0000-0003-0331-3427
Alicia OshlackMurdoch Children's Research Institute, Parkville, Australia.ORCID 0000-0001-9788-5690
Melissa H LittleMurdoch Children's Research Institute, Parkville, Australia.
Alexander N CombesMurdoch Children's Research Institute, Parkville, Australia.ORCID 0000-0001-6008-8786
The University of Melbourne · AUThe University of Queensland · AUCincinnati Children's Hospital Medical Center · USMurdoch Children's Research Institute · AU

Funding

Cell Fate Regulation of Nephron ProgenitorsR01DK100315 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI PARK, JOO-SEOP · 2014 to 2018
$1.7M
Australian Research Council DE150100652National Health and Medical Research Council GNT1063989National Health and Medical Research Council GNT1136085National Health and Medical Research Council GNT1156567NIDDK NIH HHS R01 DK100315
6 · The paper itself

Abstract

Progenitor self-renewal and differentiation is often regulated by spatially restricted cues within a tissue microenvironment. Here, we examine how progenitor cell migration impacts regionally induced commitment within the nephrogenic niche in mice. We identify a subset of cells that express

Indexed as

Cell LineageCell MovementAnimalsComputer SimulationFemaleMice, Inbred C57BLModels, BiologicalNephronsStem Cell NicheStem CellsStochastic ProcessesTranscription, GeneticWnt4 ProteinWnt4 Proteincell migrationdevelopmental biologykidney developmentmousenephron progenitorregenerative medicinesingle cell transcriptional profilingstem cellsstochastic inductionWnt4

Identifiers

PMID30676318
PMCPMC6363379
OpenAlexW2913901564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.