Evidence map›Paper›PMID 30676118›Full record

ArticleCancer investigation2019

Practice Implications of Expanded Genetic Testing in Oncology.

Diane M Korngiebel, Jennifer M Zech, Amelia Chappelle, Wylie Burke, Jan D Carline, Thomas H Gallagher, Stephanie M Fullerton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Preparing for the unexpected: Recommendations for returning secondary findings in late-stage cancer care.Genetics in medicine : official journal of the American College of Medical Genetics · 2024
    Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Diane M Korngiebela Biomedical Informatics and Medical Education , University of Washington , Seattle , WA , USA.ORCID http://orcid.org/0000-0001-5704-4416
Jennifer M Zechb ICAP, Mailman School of Public Health , Columbia University , New York , NY , USA.
Amelia Chappellec Medicine , University of Washington , Seattle , WA , USA.
Wylie Burked Bioethics and Humanities , University of Washington , Seattle , WA , USA.
Jan D Carlinea Biomedical Informatics and Medical Education , University of Washington , Seattle , WA , USA.
Thomas H Gallaghere Medicine and Bioethics and Humanities , University of Washington , Seattle , WA , USA.
Stephanie M Fullertond Bioethics and Humanities , University of Washington , Seattle , WA , USA.ORCID http://orcid.org/0000-0002-0938-6048

Funding

Ethically responsible clinical decision support for Lynch Syndrome screeningK01HG008180 · NHGRI · UNIVERSITY OF WASHINGTON · PI KORNGIEBEL, DIANE M · 2014 to 2018
$611k
Patient Safety in Genome Medicine: Learning from the Past to Safeguard the FutureR21HG007578 · NHGRI · UNIVERSITY OF WASHINGTON · PI FULLERTON, STEPHANIE MALIA · 2014 to 2015
$425k
NHGRI NIH HHS K01 HG008180NHGRI NIH HHS R21 HG007578
6 · The paper itself

Abstract

Genetic test use in oncology is growing, yet providers' experiences with evolving testing norms and their implications for patient care remain under-explored. In interviews with oncologists and cancer genetics professionals, 22 key informants described the increasing importance of germline results for therapeutic decision-making, preference for ordering tests directly rather than referring, and rapid adoption of cancer gene panels for testing. Implications for informed consent, result interpretation, and patient management were identified. These results suggest concerns raised by the transition of genetic test delivery from cancer genetics professionals to oncologists that must be addressed in practice guidelines and provider training.

Indexed as

Germ-Line MutationClinical Decision-MakingFemaleGenetic CounselingGenetic TestingHumansMaleMedical OncologyNeoplasmsPractice Guidelines as TopicQualitative ResearchCancerClinical practiceGenetic testingGenomic medicineInherited risk

Identifiers

PMID30676118
PMCPMC6410730

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.